摘要
Host-guest inclusion complexes have been extensively studied for drug delivery applications.The host molecule,typically cyclodextrin,creates a cavity,in which the guest molecule,such as a drug,can be encapsulated.This encapsulation can protect the drug from degradation,improve its solubility and stability,and enhance its bioavailability.Moreover,host-guest inclusion complexes can facilitate targeted drug delivery by selectively releasing drugs at the site of action.Various techniques,such as covalent bonding,non-covalent interactions,and self-assembly have been used to form these complexes.Host-guest inclusion complexes have shown great potential for improving the efficacy and safety of drug delivery systems.This mini review summarizes the application and recent progress of the cyclodextrin-based host-guest inclusion complex,highlighting the enhanced physicochemical and biopharmaceutical application of pharmaceutical drugs via formulation of its inclusion complex.
基金
supported by the Guangdong Postdoctoral Start-up Fund,China(No.Q0301-082)
the High-level University Construction Fund of Guangdong Province,China(Nos.02-412-2202-2123,02-410-2206298,02-412-2302-2122xM)
the Fund from He Guangzhou Science and Technology Bureau,China(No.202201010378)
the Open Project of State Key Laboratory of Respiratory Disease,China(No.SKLRD-OP-202409).
