替罗非班序贯双抗治疗载体动脉病变致穿支动脉型脑梗死溶栓后早期神经功能恶化临床观察

Effect of tirofiban sequential dual anti-infarction on early neurological deterioration in ischemic stroke caused by parent artery occluding penetrating artery after thrombolytic therapy

目的探讨替罗非班序贯双抗治疗载体动脉病变致穿支动脉型脑梗死溶栓后早期神经功能恶化(END)的效果。方法62例载体动脉病变致穿支动脉型缺血性脑梗死静脉溶栓后发生END患者,随机分为对照组(双抗治疗)和观察组(替罗非班序贯双抗治疗),各31例。比较两组治疗前、治疗2周时的美国国立卫生院卒中量表(NIHSS)、改良Rankin(mRS)、Barthel指数(BI)评分,并统计PLT、PT、APTT、Fig、hs-CRP、肝肾功能及不良反应发生情况。结果治疗2周时观察组NIHSS评分、mRS评分低于对照组,BI高于对照组(P<0.05);两组PLT、PT、APTT、Fig、hs-CRP、肝肾功能及不良反应发生率比较,差异无统计学意义(P>0.05)。结论替罗非班序贯双抗治疗可显著改善载体动脉病变致穿支动脉型缺血性脑梗死溶栓后的早期神经功能恶化。

Objective To explore the effect of tirofiban sequential dual anti-infarction on early neurological deterioration in ischemic stroke caused by parent artery occluding penetrating artery after thrombolytic therapy.Methods Sixty-two patients with early neurological deterioration in ischemic stroke due to parent artery occluding penetrating artery after thrombolytic therapy were randomly divided into observation group(tirofiban sequential dual antibody treatment)and control group(dual antibody treatment),with 31 cases in each group.Compare the National Institutes of Health Stroke Scale(NIHSS),Modified Rankin Scale(mRS),and Activity of Daily Living(ADL)scores at before treatment and at 2 weeks after treatment between two groups,and analyze the incidence of PLT,PT,APTT,Fig,hs-CRP,liver and kidney function,and adverse reactions.Results After 2 week of treatment,The NIHSS score and mRS score of the observation group were lower than those of the control group,while the BI score was higher than that of the control group(P<0.05);There was no statistically significant difference in the incidence of PLT,PT,APTT,Fig,hs-CRP,liver and kidney function,and adverse reactions between the two groups between the two groups(P>0.05).Conclusion Tirofiban sequential dual anti-infarction can significantly improve the early neurological deterioration after ischemic stroke caused by parent artery occluding penetrating artery after thrombolytic therapy thrombolysis in parent artery occluding penetrating artery.