诱导肝星状细胞铁死亡治疗肝纤维化的研究进展

Progress of researches on inducing hepatic stellate cell ferroptosis for treatment of liver fibrosis

铁死亡是一种铁依赖性的调节性细胞死亡形式,通过使肝星状细胞(HSC)失活、抑制肝纤维化和诱导肝细胞死亡参与肝纤维化发病机制,药物诱导HSC铁死亡治疗肝纤维化。探索诱导HSC铁死亡成为治疗肝纤维化的新靶点。

Emerging evidence suggests that ferroptosis,an iron-dependent form of regulated cell death,plays a critical role in the genesis of liver fibrosis through inducing hepatic stellate cell(HSC)ferroptosis to inhibit liver fibrosis or inducing hepatic ferroptosis to potentiates liver fibrosis.Pharmacologically targeting at ferroptosis with its inducers can slow down the progression of liver fibrosis in vitro and in vivo model.This review suggests that pharmacological induction of HSC ferroptosis might be used as a potential novel targeted therapy for the treatment of liver fibrosis.