Pparγ调控鱼类脂质代谢作用机制的研究进展

RESEARCH PROGRESS IN THE MECHANISM OF PparγREGULATING LIPID METABOLISM OF FISH

在集约化养殖过程中,鱼类普遍存在肝脏和腹腔脂肪过度蓄积,易导致代谢紊乱、炎症,抗逆抗病能力降低,严重制约了渔业的可持续性发展。作为脂质传感器,过氧化物酶体增殖物激活受体(PPARs)在脂肪代谢过程中起到了重要的枢纽作用。PPARs包含PPARα、PPARβ/δ和PPARγ三个亚型。其中PPARγ被认为是脂质代谢中极为关键的调控因子,在调节细胞分化、维持能量代谢稳态和炎症中也起到重要的作用。文章综述了Pparγ对鱼类脂质代谢、脂滴平衡、脂肪细胞分化的调控作用及其影响因素,以期为系统阐明Pparγ对鱼类脂代谢调控机制提供参考,为推动水产养殖业的绿色发展奠定基础。

In the process of intensive aquaculture farmed fish commonly suffer from excessive lipid accumulation,which often leads to metabolic disorders,inflammation,and reduction of disease resistance.The above problems seriously impede the sustainability of aquaculture.As lipid sensors,peroxisome proliferator-activated receptors(PPARs)play an important role in the process of lipid metabolism.PPARs includes three isoforms:PPARα,PPARβ/δand PPARγ.Notably,PPARγis considered to be an extremely critical regulator of lipid metabolism,and also plays an important role in the cell differentiation,energy metabolic homeostasis and inflammation.This paper briefly reviewed the regulatory roles of Pparγon the lipid and fatty acid metabolism,lipid droplet homeostasis,adipocyte differentiation,and its influencing factors,which provide a reference for systematically elucidating the mechanisms of Pparγon the lipid metabolism in fish,and lay the foundation for promoting the green development of aquaculture.