呋喃唑酮联合铋剂、埃索美拉唑、阿莫西林治疗HP阳性慢性胃炎患者的效果分析

Effectiveness Analysis of Furazolidone Combined with Bismuth,Esomeprazole,and Amoxicillin in Treating Patients with H.pylori Positive Chronic Gastritis

目的探讨呋喃唑酮联合铋剂、埃索美拉唑、阿莫西林治疗幽门螺旋杆菌(helicobacter pylori,HP)阳性慢性胃炎患者的效果分析。方法选择2021年3—11月深圳禾正医院收治的HP慢性胃炎患者96例作为研究对象,按照随机数表法分为A组和B组,各48例。所有患者均给予常规药物治疗,A组在常规治疗上给予克拉霉素治疗,B组在常规治疗上给予呋喃唑酮治疗。对比两组患者治疗效果、血清胃泌素(gustrin GAS)水平、HP根除情况、不良反应发生情况。结果B组的治疗总有效率为89.58%高于A组,差异有统计学意义(χ^(2)=4.376,P<0.05)。治疗前,两组患者GAS水平对比,差异无统计学意义(P>0.05);治疗后,B组GAS高于A组,差异有统计学意义(P<0.05)。A组根除HP(66.67%)低于B组(87.50%),差异有统计学意义(P<0.05)。A组的不良反应发生率为33.33%高于B组,但对比差异无统计学意义(P>0.05)。结论含有呋喃唑酮的四联方案治疗HP慢性胃炎,可通过提高根除HP率,恢复患者胃肠黏膜的分泌功能,进而提高治疗效果,且不会增加药物不良反应。

Objective To investigate the effect analysis of furazolidone combined with bismuth,esomeprazole and amoxicillin in treating patients with helicobacter pylori(HP)positive chronic gastritis.Methods 96 patients with HP chronic gastritis admitted to Shenzhen Hezheng Hospital from March to November 2021 were selected as the study subjects,and were divided into group A and group B according to the randomiz number table method,each with 48 cases.All patients were given conventional drug treatment,group A was given clarithromycin on top of conventional treatment,and group B was given furazolidone on top of conventional treatment.The treatment effect,serum gastrin(GAS)level,HP eradication,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of group B was 89.58%higher than that in group A,the difference was statistically significant(χ^(2)=4.376,P<0.05).Before treatment,there was no statistically significant difference in GAS levels between the two groups(P>0.05).After treatment,the GAS of group B was higher than that in group A,and the difference was statistically significant(P<0.05).HP eradication in group A(66.67%),which was lower than that in group B(87.50%),and the difference was statistically significant(P<0.05).The incidence of adverse reactions in group A was 33.33%higher than that in group B,but the difference was not statistically significant(P>0.05).Conclusion The quadruple regimen containing furazolidone for the treatment of HP chronic gastritis can improve the therapeutic effect by increasing the rate of HP eradication and restoring the secretory function of the gastrointestinal mucosa of the patients,and then improve the therapeutic effect,and it will not increase the adverse drug reactions.