直肠癌患者腹腔镜微创治疗对肛肠动力学和肿瘤标志物含量产生的影响分析

Analysis of the Effects of Laparoscopic Minimally Invasive Treatment of Rectal Cancer Patients on Anorectal Dynamics and Tumor Marker Levels Production

目的探索腹腔镜微创治疗直肠癌的临床价值并分析对肛肠动力学与肿瘤标志物的影响。方法选取2017年12月—2022年12月福建省老年医院接诊的60例直肠癌患者为观察对象。以随机抽签法分为两组,各30例。对照组术式为传统开腹手术,观察组术式为腹腔镜微创手术;比较两组肛肠动力学与肿瘤标志物指标、并发症发生率。结果观察组术后2周肛肠动力学指标高于对照组,差异有统计学意义(P<0.05)。肿瘤标志物方面,观察组术后8周癌胚抗原(2.12±0.71)ng/mL、糖链抗原19-9(6.42±1.61)U/mL、糖类抗原242(8.55±2.13)U/mL,均明显低于对照组的(3.61±1.12)ng/mL、(9.42±1.68)U/mL、(12.24±2.16)U/mL,差异有统计学意义(P<0.05)。观察组并发症发生率显著低于对照组,差异有统计学意义(P<0.05)。结论腹腔镜微创治疗直肠癌与传统开腹手术相比,具有较低的并发症发生率,对肛肠动力学影响较小,显著降低肿瘤标志物水平,疗效可靠。

Objective To explore the clinical value of laparoscopic minimally invasive treatment of rectal cancer and analyze the impact on anorectal dynamics and tumor markers.Methods 60 rectal cancer patients received in Fujian Geriatric Hospital from December 2017 to December 2022 were selected for observation.They were divided into two groups by random draw method,with 30 cases in each group.The operation mode of the control group was traditional open abdominal surgery,and the operation mode of the observation group was laparoscopic minimally invasive surgery.Compared of anal and intestinal dynamics and tumor marker indexes,complication rates in the two groups.Results In terms of anorectal kinetic indexes,the observation group was higher than the control group at 2 weeks postoperatively,and the difference was statistically significant(P<0.05).In terms of tumor marker levels,CEA(2.12±0.71)ng/mL,CA19-9(6.42±1.61)U/mL,and CA242(8.55±2.13)U/mL in the observation group at 8 weeks after surgery were lower than those in the control group(3.61±1.12)ng/mL,(9.42±1.68)U/mL and(12.24±2.16)U/mL,and the differ⁃ence was statistically significant(P<0.05).The incidence rate of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Laparoscopic minimally invasive treatment of rectal cancer has a lower complication rate,less impact on anorectal dynamics,significantly re⁃duces the level of tumor markers and reliable efficacy.