结核分枝杆菌毒力因子ESAT-6和CFP-10的研究进展

Advances in the virulence factors ESAT-6 and CFP-10 of Mycobacterium tuberculosis

ESAT-6和CFP-10是结核分枝杆菌中含量丰富的毒力因子,分别由RD1区相邻的基因esxA和esxB编码,二者可以协同转录形成紧密二聚体。此二聚体在破坏宿主的免疫应答、发挥毒性、参与吞噬溶酶体到宿主细胞质的易位、激活嗜中性粒细胞发挥趋化作用等生物学作用中扮演着重要角色。ESAT-6和CFP-10有良好的免疫原性,可应用于结核病的诊断和疫苗研究。进一步探索它们的分子结构和致病机制可为结核病的预防、诊断和治疗提供新思路。

ESAT-6 and CFP-10 are abundant virulence factors in Mycobacterium tuberculosis,which are encoded by two adjacent esxA and esxB genes in RD1,and they can synergically transcribe to form a compact dimer.This dimer plays an important role in pathogenic mechanisms such as destroying the host immune response,exerting toxicity,participating in the translocation of phagolysosomes into the host cytoplasm,and activating neutrophils to exert chemotaxis.In addtion,ESAT-6 and CFP-10 can be used in the diagnosis and vaccine research of tuberculosis since they are immunogenic.Further exploration of their molecular structure and pathogenesis may provide new ideas for the prevention,diagnosis and treatment of tuberculosis.