奥密克戎变异株老年重症感染者细胞免疫指标对预后的价值研究

A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients

目的 探讨奥密克戎变异株老年重症感染者的临床细胞免疫学指标特征及其与预后的关系。方法 回顾性分析2022年12月至2023年2月昆明医科大学第一附属医院老年ICU收治的53例奥密克戎变异株感染者的临床资料,将其分为存活组(n=22)、死亡组(n=31),进行组间比较。采用Logistic分析确定奥密克戎变异株老年重症感染者的预后因素并构建ROC曲线。结果 多因素Logistic分析显示IL-6升高(P=0.043)和T淋巴细胞绝对值下降(P=0.011)是预后的独立危险因素。使用IL-6、T淋巴细胞绝对值和二者联合进行Logistic回归分析所得到的值分别构建ROC曲线,得到的曲线下面积分别为0.818、0.796和0.887。结论 IL-6升高及T淋巴细胞绝对值下降是奥密克戎变异株老年重症感染者预后的独立危险因素。

Objective To investigate the characteristics of clinical cellular immunity and its relationship with prognosis in elderly patients with severe infection caused by Omicron variant.Methods The clinical data of 53 patients with Omicron variant infection admitted to the geriatric Intensive Care Unit of the First Affiliated Hospital of Kunming Medical University from December 2022 to February 2023 were retrospectively analyzed.The patients were divided into 22 survival cases and 31 death cases for comparison between the two groups.Logistic analysis is adopted to define the omicron variants of elderly severe infections prognostic factors and construct the ROC curve.Results Multivariate logistic analysis revealed that the independent risk factors were elevated IL-6(P=0.043)and decreased absolute T lymphocyte count(P=0.011).AUC value of ROC of IL-6,absolute T lymphocyte count and IL-6 combined with absolute T lymphocyte count was 0.818,0.796 and 0.887.Conclusion Elevated IL-6 and decreased absolute T lymphocyte count are independent risk factors for elderly severe patients with Omicron variant infections.