帕罗西汀在江苏省某三级精神专科医院门诊患者中的使用情况

Use of Paroxetine in Outpatients of a Tertiary Psychiatric Hospital in Jiangsu Province

目的评价门诊患者帕罗西汀的临床应用情况。方法采用回顾性分析,收集医院2020年1月1日至2023年6月30日所有使用过帕罗西汀门诊患者的处方信息,分析患者的结构特征及用药量、频率、费用等信息,评估处方的合理性。结果共纳入帕罗西汀有效处方28106张,其中男性9257例,女性18849例;盐酸帕罗西汀片的使用量逐年下降,盐酸帕罗西汀肠溶缓释片的使用量逐年上升;患者人均单位剂量的药费金额逐年上升;存在超适应症、剂量不规范、超疗程、儿童和青少年超说明书用药等不合格处方。结论帕罗西汀的临床应用存在用药不规范、超说明书用药等不合理情况,需进一步加强帕罗西汀在门诊患者中的用药管理。

Objective To evaluate the clinical application of paroxetine in outpatients.Methods A retrospective analysis was used to collect the prescription information of all outpatients who used paroxetine in the hospital from January 1,2020 to June 30,2023.The structural characteristics of patients and information on medication dosage,frequency,and cost were analyzed to evaluate the rationality of prescriptions.Results A total of 28,106 valid prescriptions for paroxetine were included,of which 9257 were male and 18849 were female.The use of paroxetine hydrochloride tablets decreased annually while the use of enteric-coated paroxetine hydrochloride sustained-release tablets increased annually.The annual use of paroxetine hydrochloride tablets decreased,while the annual use of enteric-coated paroxetine hydrochloride sustained-release tablets increased.The average cost of the drug per patient unit dose increased each year.Non-compliant prescriptions included off-label use,improper dosage,excessive treatment duration,and off-label use in children and adolescents.Conclusion The clinical application of paroxetine is not standardized,and there are unreasonable situations such as overuse.It is necessary to further strengthen the medication management of paroxetine in outpatient patients.