干细胞的干性机制及其在前列腺癌诊疗中的研究进展

Stem cell stemness mechanisms and their role in the management of prostate cancer

前列腺癌是泌尿系最常的恶性肿瘤之一,手术、放化疗和免疫治疗是前列腺癌的主要治疗方式,由于肿瘤具有明显的异质性,导致患者的疗效往往不尽如人意。近年来,分化不良、具有自我更新能力的癌症启动点和抵抗治疗的癌症干细胞(CSC)成为前列腺癌研究的热点和焦点。CSC与相邻的其他肿瘤细胞具有不同的生物学特性,在前列腺癌发生、发展中扮演着非常重要的角色,靶向前列腺癌干细胞是一种极具潜力的新型疗法。本文就CSC的干性维持机制、对肿瘤微环境的影响,以及其在前列腺癌治疗中的相关研究进展进行综述,为前列腺癌干细胞的靶向治疗提供理论依据。

Prostate cancer is one of the most frequent malignancies of the urological tract.Surgery,radiotherapy,and immunotherapy are the main treatment methods for prostate cancer,which often lead to unsatisfactory outcomes due to the obvious heterogeneity of the tumor.Recently,poorly differentiated,selfrenewing cancer initiation sites and treatment-resistant cancer stem cells(CSC)have become a hot topic in prostate cancer research.Targeting prostate cancer stem cells is a novel and promising therapy.In this article,we review the mechanism of stemness maintenance of CSC,its impact on the tumor microenvironment,and the related research progress in prostate cancer treatment,providing a theoretical basis for the targeted therapy of prostate cancer stem cells.