双相情感障碍认知功能损害与脑源性神经营养因子基因遗传学研究的进展

Research progress on cognitive impairment in bipolar disorder and genetic inheritance of brainderived neurotrophic factor

双相情感障碍(BD)患者存在持续的认知功能损害,这种损害可对患者的病程以及预后产生不利影响。脑源性神经营养因子(BDNF)是神经生长因子家族的一种神经营养因子,参与神经元的发生、存活以及突触可塑性,与BD患者认知功能损害密切相关。本文综述了BDNF表达水平、基因多态性与BD认知功能损害的关系,BDNF表观遗传学与BD及认知功能损害的研究,为早期识别及治疗BD患者认知功能损害提供理论依据。

Patients with bipolar disorder(BD)exhibit persistent cognitive impairment,which hasadverse effects on the course and prognosis of the disease.Brain-derived neurotrophic factor(BDNF)is a typeof neurotrophic factor in the family of nerve growth factors,which is involved in the genesis,survival,andsynaptic plasticity of neurons,and is closely related to cognitive impairment in BD patients.This paper reviewsthe relationship between BDNF expression levels,gene polymorphisms,and cognitive impairment in BD,aswell as the study of BDNF epigenetics,BD and cognitive impairment,aiming to provide a theoretical basis forearly identification and treatment of cognitive impairment in BD patients.