铁死亡在口腔疾病中的研究进展

Ferroptosis and its implication in oral diseases

铁死亡是一种可调控的,具有铁依赖性的,由脂质过氧化驱动的细胞死亡形式,是一种重要的细胞死亡形式,在多种疾病中发挥着重要作用。目前铁死亡在癌症、缺血/再灌注损伤疾病、各类神经退行性疾病等方面的研究取得了一定的成果,在口腔疾病中的作用也越来越受关注。铁死亡是口腔癌的新兴治疗靶点。许多炎症损伤疾病与铁死亡相关,牙周炎作为一种慢性炎症性疾病,与铁死亡的发生过程可能存在一定的相关性。本文就目前铁死亡与口腔疾病的相关研究及发现进行综述,旨在为探索口腔疾病的发病机制和诊疗提供参考。

Ferroptosis is a regulated,iron-dependent form of cell death driven by lipid peroxidation and plays an important role in a variety of diseases.It has been studied in cancer,ischemia/reperfusion injury diseases,and neurodegenerative diseases.As an important form of cell death,ferroptosis has received increasing attention in oral disease research.Some advances have been achieved in related studies.Ferroptosis has become an emerging therapeutic target for oral cancer and has been associated with many inflammatory injury diseases.As a chronic inflammatory disease,periodontitis may have some correlation with ferroptosis.This work reviews current findings on ferroptosis to provide a reference for the mechanism,diagnosis,and treatment of related oral diseases.