线粒体自噬在牙周炎发生发展过程中的研究进展

Research progress of mitophagy in the onset and development of periodontal disease

牙周炎是一种由菌斑生物膜引起牙周支持组织破坏的慢性炎症性疾病,主要以牙龈炎症和牙槽骨进行性破坏为特征。线粒体自噬是通过自噬选择性清除细胞内功能失调或受损的线粒体来调节细胞内稳态的主要机制,在线粒体质量和数量控制中发挥关键作用。近年来有研究发现:线粒体自噬可以通过抑制牙周炎症反应、降低细胞凋亡、促进牙周韧带干细胞成骨分化等多种途径参与牙周病的发生和发展,为牙周病的治疗提供了有前景的治疗靶点。本文就线粒体自噬的分子机制及其在牙周病发生发展中的作用等方面的研究进展作一综述。

Periodontal disease is a chronic inflammatory disease leading to the destruction of periodontal tissues caused by dental plaque biofilm.It is characterized by gingival inflammation and progressive destruction of alveolar bone.Mitophagy is a major mechanism that regulates cellular homeostasis by selectively eliminating dysfunctional or damaged mitochondria through autophagy,which plays a critical role in the mitochondrial quality and quantity control.Recent studies indicated that mitophagy participates in the development of periodontal diseases by inhibiting periodontal inflammation,decreasing cell apoptosis,and promoting osteogenic differentiation in periodontal ligament stem cells.Moreover,it provides a promising therapeutic strategy for the treatment of periodontal disease.Therefore,this review summarizes the progress of research on the definition of mitophagy,its molecular mechanism,and the role of mitophagy in the onset and development of periodontal disease.