蠕虫感染调控宿主1/2类免疫应答的分子机制研究进展

Progress of researches on molecular mechanisms underlying helminth infection⁃mediated type 1/2 host immune responses

蠕虫感染遍布全球,严重威胁人类健康以及畜牧业发展。阐明蠕虫与宿主间的相互作用是有效控制并最终根除相关疾病的关键。蠕虫感染宿主后首先启动固有免疫应答,进而介导适应性免疫应答,在感染早期以1类免疫应答为主,主要发挥抗感染作用;后期则以2类免疫应答为主,与蠕虫免疫逃避、加重组织损伤相关。本文就蠕虫感染宿主后参与调控1/2类免疫应答相关信号通路的研究进展进行综述。

Helminth infections are widespread worldwide,and pose a serious threat to human health and animal husbandry development.Understanding of helminth⁃host interactions is critical to effective control and ultimate eradication of helminthiasis.Following host infections,helminth infections firstly initiate innate immune responses and then mediate adaptive immune responses.Type 1 immune responses are predominant at early stage of helminth infections,which mainly play anti⁃infective actions,and type 2 immune responses are predominant at late stage of infections,which are associated with helminth immune evasion and aggravation of tissue damages.This review summarizes the progress of researches on type 1/2 immune responses⁃associated signaling pathways mediated by helminth infections in hosts.