天然产物抗血管内皮生长因子及其受体抑制肿瘤血管生成作用研究进展

Research progress of natural products against VEGF/VEGFRs to inhibit tumor angiogenesis

肿瘤血管生成是肿瘤生长和转移的关键过程,也是抗肿瘤治疗的重要靶点。血管内皮生长因子(VEGF)及其受体(VEGFRs)在肿瘤血管生成过程中可诱导广谱的信号转导级联反应,是血管形成的关键介质。多种天然产物及其衍生物已被证实可通过抑制VEGF/VEGFRs信号通路,发挥良好的抗肿瘤血管生成作用,有望开发出新的、高效、低毒的抗肿瘤血管生成候选药物。文章综述了近年来国内外关于天然产物抗VEGF/VEGFRs抑制肿瘤血管生成作用的研究进展。

Tumor angiogenesis is the key process of tumor growth and metastasis,and it is also an important target of anti-tumor therapy.VEGF/VEGFRs can induce a broad spectrum signal transduction cascade during tumor angiogenesis and is a key mediator in angiogenesis.A variety of natural products and their derivatives have been proven to play a good role in antitumor angiogenesis by inhibiting the VEGF/VEGFRs signaling pathway,and it is expected to develop new,efficient and lowtoxicity anti-tumor angiogenesis drug candidates.In this paper,the recent research progress on the anti-VEGF/VEGFRs effect of natural products on tumor angiogenesis was reviewed.