^(125)I粒子治疗恶性肿瘤的分子生物学机制研究进展

Research progress in the molecular biological mechanism of ^(125)I seed in the treatment of malignant tumors

碘-125(iodine-125,^(125)I)粒子组织间植入是一种持续低剂量率内照射治疗方式,现已应用于多种恶性肿瘤的治疗。近年来,^(125)I粒子治疗恶性肿瘤的分子生物学研究逐渐开展并深入。^(125)I粒子除损伤DNA外还作用于内质网和线粒体,进而通过多条信号通路诱导肿瘤细胞凋亡和类凋亡、促进细胞保护性自噬、抑制肿瘤细胞上皮间质转化。此外,^(125)I粒子还能改善肿瘤微环境,通过抑制肿瘤微血管、激活免疫应答,从而抑制肿瘤生长。本文就^(125)I粒子诱导的上述生物学效应及相关分子机制进行综述,旨在为后续的机制研究和联合治疗提供思路。

Interstitial implantation of ^(125)I seeds is a kind of continuous low-dose-rate internal irradiation therapy,and it has been used in the treatment of various malignant tumors.In recent years,molecular biology research on the treatment of malignant tumors with ^(125)I seeds has been gradually carried out and deepened.In addition to damaging DNA,^(125)I seeds also act on the endoplasmic reticulum and mitochondria,and then,through multiple signaling pathways,induce tumor cells apoptosis and paraptosis,promote cytoprotective autophagy,and inhibit epithelial-mesenchymal transition of tumor cells.Moreover,^(125)I seeds can also improve the tumor microenvironment.^(125)I seeds can suppress tumor growth by inhibiting tumor microvessels and activating the immune response.This paper reviews the above-mentioned biological effects and related molecular mechanisms induced by ^(125)I seeds,aiming to provide ideas for future mechanism research and combination therapy.