痰热清雾化吸入联合体外排痰技术治疗老年慢阻肺急性加重期患者排痰效果观察

Clinical observation on Tanreqing nebulization inhalation combined with extracorporeal phlegm ejection technology on phlegm ejection in elderly patients with acute aggravation of chronic obstructive pulmonary disease

目的观察痰热清雾化吸入联合体外排痰技术治疗老年慢阻肺急性加重期(AECOPD)患者排痰效果。方法将我院105例老年AECOPD患者随机分为观察组53例与对照组各52例。对照组在常规疗法基础上联合体外排痰技术,观察组在对照组治疗基础上予痰热清雾化吸入。比较两组总显效率、总有效率。记录并比较治疗第1、3、7天痰量。测定并比较第1s用力呼气量(FEV1),用力肺活量(FVC),第1s用力呼吸量容积率(FEV1/FVC)、白细胞计数(WBC)、中性粒细胞(Neutrophil)百分比、C反应蛋白(CRP)、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))值。结果治疗后,观察组总显效率、总有效率均高于对照组(P<0.05);观察组治疗第1、3、7天痰量均多于对照组(P<0.05);两组FEV1、FVC、FEV1/FVC值,均高于治疗前,观察组FEV1、FVC、FEV1/FVC值均高于对照组(P<0.05);两组WBC、Neutrophil、CRP值均低于治疗前,观察组WBC、Neutrophil、CRP值均低于对照组(P<0.05);两组PaO_(2)高于治疗前,PaCO_(2)低于治疗前,观察组PaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05)。结论痰热清雾化吸入联合体外排痰技术对老年AECOPD患者的排痰效果肯定,提高肺功能,下调炎性反应,改善血气指标。

Objective To observe the effect of Tanreqing nebulization inhalation combined with extracorporeal sputum ejection technology on sputum excretion in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 105 elderly AECOPD patients were randomly divided into observation group of 53 cases and control group of 52 cases.Control group was treated with conventional therapy combined with extracorporeal sputum ejection technology,while observation group was treated with Tanreqing nebulized inhalation on the basis of control group.The total apparent efficiency and total effective efficiency were compared between the two groups.The sputum volume on the 1st,3rd,and 7th days of treatment were recorded and compared.The first second forced expiratory volume(FEV1),forced vital capacity(FVC),first second forced respiratory volume ratio(FEV1/FVC),white blood cell count(WBC),Neutrophil percentage,Creactive protein(CRP),arterial oxygen partial pressure(PaO_(2)),and arterial carbon dioxide partial pressure(PaCO_(2))were measured and compared.Results After treatment the total effective rate and total effective rate of observation group were higher than those of control group(P<0.05);the sputum volume of observation group on the 1st,3rd,and 7th day of treatment was higher than that of control group(P<0.05);the FEV1,FVC,and FEV1/FVC values of both groups were higher than before treatment,and were higher in observation group than control group(P<0.05);the WBC,Neutral,and CRP values of both groups were lower than before treatment,and were lower in observation group than control group(P<0.05);PaO_(2) in both groups was higher than before treatment,and were higher in observation group than control group(P<0.05);while PaCO_(2) was lower in both groups than before treatment,and was lower in control group than observation group(P<0.05).Conclusion The combination of Tanreqing nebulization inhalation and extracorporeal sputum ejection technology has a positive sputum ejection effect on elderly AECOPD patients,improving lung function,downregulating inflammatory reactions,and improving blood gas indicators.