无机纳米材料用于声动力治疗的研究进展

A Review of the Application of Inorganic Nanomaterials in Sonodynamic Therapy

声动力治疗是一种新型肿瘤治疗方式,因具有非侵入性、高穿透性、高安全性、时空可控性等优点,近年来受到研究人员的广泛关注。声动力治疗依赖声敏剂在低频超声下产生的空化泡和活性氧对肿瘤组织产生化学损伤和机械损伤。现有声敏剂主要可以分为有机声敏剂、无机声敏剂和有机无机杂化声敏剂,其中无机声敏剂由于具有高超声稳定性、多功能性、易合成、易表面修饰等优点近年来广受关注。本文着重介绍了声动力治疗中化学损伤和机械损伤的产生机制,并基于声敏剂的作用机制对已有无机声敏剂的设计进行总结与展望。

Sonodynamic therapy is a novel and promising antitumor therapy,with advantages of non-invasiveness,deep penetration,high-level of safety and spatiotemporal selectivity.Under low frequency ultrasound,sonodynamic therapy could cause tissue damage via redox oxygen species and cavitation.The existing sonosensitizers can be divided into organic sonosensitizers,inorganic sonosensitizers and organic/inorganic hybrid sonosensitizers.Inorganic sonosensitizers have been highly focused recently because of high ultrasonic stability,versatility,simple synthesis and easy surface modification.In this review,we focused on the mechanism of chemical and mechanical damage in sonodynamic therapy,summarized the existing inorganic sonosensitizers based on mechanism,and pointed out challenges and possible solutions.