基于数据挖掘李佃贵教授治疗萎缩性胃炎伴幽门螺杆菌感染相关疾病用药规律

Study on Professor Diangui Li's Medication Experience in Treating Atrophic Gastritis Concomitant with Helicobacter Pylori Infection Based on Data Mining

目的:基于数据挖掘技术研究国医大师李佃贵治疗萎缩性胃炎(atrophic gastritis,AG)伴幽门螺杆菌(Helicobacter pylori,Hp)感染相关疾病用药规律,为临床治疗相关疾病提供参考价值。方法:收集李佃贵教授自2019年5月至2022年12月就诊于河北省中医院名医堂,处方为患者初次就诊中药处方,运用名医传承辅助平台进行中药频数分析、中药关联规则分析和聚类分析。结果:该研究共收集有效初诊处方188首,中药总数为136味,中药出现总频数为4108次,中药使用频数最多为185次,频数最低为1次,高频药物有28味,频数前10的中药有:白花蛇舌草、黄连、茵陈、鸡骨草、白芍、当归、半枝莲、百合、枳实、川芎。高频中药功效以清热药、理气药为主;药味以辛、苦、甘为主;药性以温、寒、平为主;归经以脾、肝、胃为主。核心中药有:黄连、茵陈、白芍、当归等;关联规则结果有:鸡骨草-苦参、绞股蓝-板蓝根、黄芩-板蓝根等;聚类分析结果展示有10簇如:(1)茵陈、黄连、白花蛇舌草、半枝莲、鸡骨草;(2)白芍、当归、川芎、乌药;(3)元胡、丹参、白芷。结论:李佃贵教授治疗萎缩性胃炎AG伴幽门螺杆菌Hp感染相关疾病以清热解毒、理气化痰药为主,辨病与辨证相结合,攻补兼施,调整人体机制。

Objective Our objective was to explore the national traditional Chinese medicine by studying master Diangui Li's medication experience in treating atrophic gastritis(AG)concomitant with Helicobacter pylori(Hp)infection based on data mining,and to provide the reference for the clinical treatment of relevant diseases.Methods The Chinese medicine prescriptions of the patients'first visits to the Famous Doctors'Consultation Room in Hebei Provincial Hospital of Chinese Medicine from May 2019 to December 2022 were collected and frequency analysis of the Chinese herbs,association rules analysis of the Chinese herbs,and cluster analysis were conducted using the Famous Doctor Inheritance Assistance Platform.ResultsA total of 188 prescriptions were collected,with 136 kinds of Chinese herbs.The highest use frequency of Chinese herbs was 185 and the lowest was 1.There were 28 kinds of Chinese herbs with high use frequency.The top 10 herbs with the high use frequency include Baihuasheshecao(Hedyotis Diffusae Herba),Huanglian(Coptidis Rhizoma),Yinchen(Artemisiae Scopariae Herba),jigucao(Abriherba),Baishao(Paeoniae Radix Alba),Danggui(Angelicae Sinensis Radix),Banzhilian(Scutellariae Barbatae Herba),Baihe(Lili Bulbus),Zhishi(Auranti Immaturus Fructus),Chuanxiong(Chuanxiong Rhizoma).Chinese herbs with high frequency use are mostly heat-clearing herbs and qi-regulating herbs;the flavors of the herbs are mainly pungent,bitter,and sweet;the properties are mainly warm,cold,and neutral;the meridian tropism is mainly the spleen,liver,and stomach meridians.The core herbal medicines are Huanglian(Coptidis Rhizoma),Yinchen(Artemisiae Scopariae Herba),Baishao(Paeoniae Radix Alba),Danggui(Angelicae Sinensis Radix),etc.;the results of association rules:Jigucao(Abriherba)-Kushen(Sophorae Flavescentis Radix),Jjiaogulan(Gynostemmatis Pentaphylli Rhizoma seu Herba)-Banlangen(lsatidis Radix),Huangqin(Scutellariae Radix)-Banlangen(lsatidis Radix),etc.;the results of cluster analysis showed that there were 10 clusters:(1)Yinchen(Artemisiae Scopariae Herba),Huanglian(Coptidis Rhizoma),Baihuasheshecao(Hedyotis Diffusae Herba),Banzhilian(Scutellariae Barbatae Herba),Jigucao(Abriherba);(2)Baishao(Paeoniae Radix Alba),Danggui(Angelicae Sinensis Radix),Chuanxiong(Chuanxiong Rhizoma),Wuyao(Linderae Radix);(3)Yuanhu(Corydalis Rhizoma),Danshen(Salviae Miltiorrhizae Radix et Rhizoma),Baizhi(Angelicae Dahuricae Radix).Conclusions For the treatment of AG concomitant with Hp infection,Professor Diangui Li mainly adopts the method of clearing heat and removing the toxin,regulating qi and resolving phlegm,combining disease differentiation with syndrome differentiation,performing reinforcing method,and reducing method simultaneously to regulate the mechanism of the human body.