右佐匹克隆辅助治疗精神分裂症并发睡眠障碍的临床疗效

Clinical efficacy of dexzopiclone in the adjuvant treatment of schizophrenia complicated with sleep disorder

目的 观察右佐匹克隆辅助治疗精神分裂症并发睡眠障碍的临床疗效。方法 选取2021年10月—2022年10月厦门市仙岳医院收治的精神分裂症并发睡眠障碍患者92例,按照随机数字表法分为常规组46例与试验组46例。常规组予以阿立哌唑片、氯硝西泮片,试验组在常规组基础上加用右佐匹克隆片,2组均连续治疗21 d。比较2组临床疗效,用药前与用药21 d后匹兹堡睡眠质量指数(PSQI)评分、阳性和阴性精神症状评定量表(PANSS)评分、蒙特利尔认知评估量表(MoCA)评分、简易精神状态检查量表(MMSE)评分,不良反应。结果 试验组总有效率高于常规组(97.83%vs.82.61%,χ^(2)=4.434,P=0.035)。用药21 d后,2组睡眠时间、睡眠质量、入睡时间、睡眠效率、睡眠障碍、日间功能障碍评分及总分低于用药前,且试验组低于常规组(P<0.01);2组阳性症状、阴性症状、一般精神病理评分低于用药前,且试验组低于常规组(P<0.01);2组MoCA评分、MMSE评分高于用药前,且试验组高于常规组(P<0.01)。试验组与常规组不良反应总发生率比较,差异无统计学意义(4.35%vs.15.22%,χ^(2)=1.971,P=0.160)。结论 右佐匹克隆辅助治疗精神分裂症并发睡眠障碍可提高临床疗效,并可有效改善患者睡眠质量,减轻精神行为症状,提高认知功能,且安全性较高。

Objective To observe the clinical efficacy of dexzopiclone in the adjuvant treatment of schizophrenia complicated with sleep disorder.Methods A total of 92 cases of schizophrenia patients complicated with sleep disorder were selected from October 2021 to October 2022 in Xiamen Xianyue Hospital,which were divided into the conventional group and the experimental group according to the random number table method,46 cases in each group.The conventional group was given aripiprazole tablets and clonazepam tablets,while the experimental group was given dexzopiclone tablets in addition to the conventional group.Both groups were treated continuously for 21 days.Clinical efficacy,PSQI score,PANSS score,MoCA score,MMSE score before medication and at 21 days after medication and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the conventional group(97.83% vs.82.61%,χ^(2)=4.929,P=0.026).After 21 days of medication,scores of sleep time,sleep quality,sleep time,sleep efficiency,sleep disorder and daytime dysfunction and total score in the two groups were lower than those before medication,and the experimental group were lower than those in the conventional group(P<0.01);Scores of positive symptoms,negative symptoms and general psychopathology in the two groups were lower than those before medication,and those in the experimental group were lower than those in the conventional group(P<0.01);MoCA score and MMSE score of the two groups were higher than those of before medication,and the experimental group were higher than those of the conventional group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the experimental group and the conventional group(4.35% vs.15.22%,χ^(2)=1.971,P=0.160).Conclusion Dexzopiclone can improve the clinical efficacy in the adjuvant treatment of schizophrenia complicated with sleep disorder,which can effectively improve the sleep quality of patients,relieve mental and behavioral symptoms,and improve cognitive function,and with higher safety.