活血化瘀方加减治疗AECOPD的临床效果

Clinical effect of Huoxue Huayu recipe in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的 观察活血化瘀方加减治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法 选择2021年4月—2022年4月漳州市第二中医院收治的AECOPD患者80例为研究对象,根据随机抽签法分为观察组和对照组各40例。对照组行常规西药治疗,观察组在常规西药治疗的基础上辅以活血化瘀方加减治疗,2组均治疗14 d。比较2组临床疗效、治疗前后中医证候积分、肺功能指标、血气分析指标、血液流变学指标及炎性反应指标。结果 观察组患者临床治疗总有效率为95.00%,高于对照组的80.00%(χ^(2)=4.114,P=0.043)。治疗14 d后,2组患者主症积分、次症积分及总分均低于治疗前,用力肺活量(FVC)、第1秒用力呼气容积(FVE_(1))占预计值百分比(FVE_(1)%pred)、FVE_(1)与FVC比值(FVE_(1)/FVC)均高于治疗前,且观察组变化幅度大于对照组(P<0.05或P<0.01);2组患者动脉血氧分压(PaO_(2))高于治疗前,动脉血二氧化碳分压(PaCO_(2))、全血高切黏度(HBV)、全血低切黏度(LBV)、白细胞计数(WBC)、C反应蛋白(CRP)均低于治疗前,且观察组变化幅度大于对照组(P<0.05或P<0.01)。结论 活血化瘀方加减治疗AECOPD的效果较好,对症状改善、机体功能恢复、炎性反应减轻等有积极影响。

Objective To observe the clinical effect of Huoxue Huayu recipe in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 80 patients with AECOPD admitted to Zhangzhou Second Hospital of Traditional Chinese Medicine from April 2021 to April 2022 were selected as the research objects,and according to random drawing,they were divided into observation group and control group,40 cases in each group.The control group received conventional western medicine treatment,and the observation group was supplemented with Huoxue Huayu recipe on the basis of conventional western medicine treatment,the two groups were treated for 14 days.The clinical efficacy,TCM syndrome scores,pulmonary function indexes,blood gas analysis indexes,hemorheology indexes and inflammatory reaction indexes before and after treatment were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 95.00%,which was higher than 80.00% in the control group(χ^(2)=4.114,P=0.043).After 14 days of treatment,the main symptom score,secondary symptom score and total score of the two groups were lower than those before treatment,and the percentage of forced vital capacity(FVC) and forced expiratory volume in one second(FVE_(1)) to the predicted value(FVE_(1)%pred) and FVE_(1)/FVC were higher than those before treatment,and the changes in the observation group were greater than those in the control group(P<0.05 or P<0.01);The partial pressure of oxygen in arterial blood(PaO_(2)) in the two groups was higher than that before treatment,the partial pressure of carbon dioxide in arterial blood(PaCO_(2)),high whole blood viscosity(HBV),low whole blood viscosity(LBV) were higher than those before treatment,white blood cell count(WBC),and C reactive protein(CRP) were lower than those before treatment,and the changes in the observation group were greater than those in the control group(P<0.05 or P<0.01).Conclusion Huoxue Huayu recipe has a good effect in the treatment of AECOPD,and has positive effect on symptom improvement,body function recovery,and inflammatory response reduction.