头孢他啶与头孢噻肟联合青霉素治疗新生儿感染性肺炎的疗效比较

Comparison of the efficacy of ceftazidime and cefotaxime combined with penicillin in the treatment of neonatal infectious pneumonia

目的比较头孢他啶与头孢噻肟联合青霉素治疗新生儿感染性肺炎的疗效。方法选取2022年1—12月宁德师范学院附属宁德市医院收治的新生儿感染性肺炎患儿70例,根据随机数字表法分为研究组和对照组,各35例。研究组予头孢他啶联合青霉素治疗,对照组予头孢噻肟联合青霉素治疗,2组均治疗1周。比较2组临床疗效,治疗前后炎性因子指标、症状消失时间、体质量增长情况及不良反应。结果研究组治疗总有效率为97.14%,高于对照组的82.86%(χ^(2)=3.968,P=0.046);治疗1周后,2组超敏C反应蛋白、降钙素原水平均较治疗前降低,且研究组低于对照组(P均<0.01);研究组发热、气促、肺部啰音消失时间均短于对照组(P均<0.01);治疗1周后,研究组与对照组体质量增长比较差异无统计学意义(t=0.613,P=0.542);研究组与对照组不良反应总发生率比较差异无统计学意义(11.43%vs.5.71%,χ^(2)=0.729,P=0.393)。结论头孢他啶与头孢噻肟分别联合青霉素治疗新生儿感染性肺炎安全性均有保障,但头孢他啶联合青霉素治疗可增强疗效,较快改善患儿炎性反应,加快症状消失时间,达到促进康复的效果。

Objective To compare the efficacy of ceftazidime and cefotaxime combined with penicillin in the treatment of neonatal infectious pneumonia.Methods A total of 70 children with neonatal infectious pneumonia admitted to Ningde Municipal Hospital of Ningde Normal University from January to December 2022 were selected and divided into the study group and the control group according to the random number table method,with 35 cases in each group.The study group was treated with ceftazidime combined with penicillin,and the control group was treated with cefotaxime combined with penicillin.Both groups were treated for 1 week.The clinical efficacy,inflammatory factor indexes before and after treatment,symptom disappearance time,body mass growth and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 97.14%,which was higher than 82.86%of the control group(χ^(2)=3.968,P=0.046).After one week of treatment,the levels of high-sensitivity C-reactive protein and procalcitonin in the two groups were lower than those before treatment,and the levels of study group were lower than control group(P<0.01).The disappearance times of fever,shortness of breath and pulmonary rales in the study group were shorter than control group(P<0.01).After one week of treatment,there was no statistically significant difference in body mass growth between the study group and the control group(t=0.613,P=0.542).There was no significant difference in the total incidence of adverse reactions between the study group and the control group(11.43%vs.5.71%,χ^(2)=0.729,P=0.393).Conclusion The safety of combining cefotaxime or cefoperazone with penicillin for treating neonatal infectious pneumonia is guaranteed.However,the combination of cefotaxime and penicillin enhances efficacy and rapidly improves inflammatory responses in affected infants,resulting in shorter symptom disappearance time and achieving better recovery outcomes.