基于CiteSpace对近10年脑出血信号通路研究进展的可视化分析

CiteSpace-based visual analysis of research progress on intracerebral hemorrhage-related signaling pathways in recent 10 years

目的通过对脑出血信号通路相关研究进行文献计量学统计及可视化分析,探讨近10年该领域的研究热点和发展趋势。方法基于Web of Science核心合集Science Citation Index Expanded数据库,利用CiteSpace分析软件对近10年发表的文章进行文献计量学统计及可视化分析。结果通过对796篇脑出血信号通路领域文献进行可视化分析显示,该领域发文量呈逐年上涨趋势,中国是发文量最多的国家,发文量最多的机构为洛马林达大学,资助该领域最多的基金资助机构是中国国家自然科学基金委员会,关键词分析结果显示研究热点方向集中在炎症反应、氧化应激反应、miRNA基因表达、核因子-κB(NF-κB)信号通路、细胞外调节蛋白激酶1/2信号通路、脂质信号分子鞘氨醇-1-磷酸及头针治疗等。结论应用CiteSpace可视化分析方法可直观的展示出脑出血相关信号通路的研究热点和趋势,为脑出血的治疗和预防打开新的窗口。

Objective To explore the hotspots and trend of research on the signaling pathways of intracerebral hemorrhage in the past 10 years through bibliometrics and visual analysis.Methods We used CiteSpace to perform bibliometrics and visual analysis on relevant articles published in the recent 10 years,which were obtained from the Science Citation Index Expanded database of the Web of Science Core Collection.Results According to visual analysis of 796 pieces of literature on intracerebral hemorrhage-related signaling pathways,there is a growing number of papers published in this field.China was the country with the largest number of papers published.Loma Linda University was the institution with the largest number of papers published.The funding institution sponsoring most in this field was the National Natural Science Foundation of China.The keyword analysis showed that the research focused on inflammatory reactions,oxidative stress,microRNA gene expression,nuclear factor-kappa B signaling pathways,extracellular regulated protein kinase 1/2 signaling pathways,the lipid-signaling molecule sphingosine-1-phosphate,and scalp acupuncture therapy.Conclusion CiteSpacebased visual analysis can directly display the research hotspots and trend of intracerebral hemorrhage-related signaling pathways,providing new insights into the treatment and prevention of intracerebral hemorrhage.