甘油三酯-葡萄糖指数与缺血性脑卒中的研究进展

Research advances in the value of triglyceride-glucose index in ischemic stroke

研究脑卒中危险因素对早期识别高危人群、改善预后具有重要意义。研究证实胰岛素抵抗(IR)是脑血管疾病的独立危险因素。甘油三酯-葡萄糖(TyG)指数,作为一种简便可靠的胰岛素抵抗替代指标,TyG指数具有很大的潜在价值。较高的TyG指数与动脉粥样硬化、颈总动脉内膜中膜厚度、斑块不稳定、心血管疾病的发病率增加有关。大量证据证明TyG指数可以预测缺血性卒中的发病风险。TyG指数与缺血性卒中不良临床后果独立相关,可加剧住院期间神经系统恶化,引发缺血性卒中复发。TyG指数高的个体更容易发生脑血管疾病,并观察到潜在的线性剂量-反应关系。本文系统地总结了TyG指数与卒中发生之间关联的证据,探讨TyG指数在优化缺血性卒中风险分层中的价值。

The research on risk factors for stroke is of great significance for the early identification of high-risk groups and the improvement of prognosis.Studies have confirmed that insulin resistance(IR)is an independent risk factor for cerebrovascular diseases.Triglyceride-glucose(TyG)index has a great potential value as a simple and reliable alternative index for IR.A relatively high TyG index is associated with increases in atherosclerosis,carotid intima-media thickness,carotid plaque instability,and the incidence rate of cardiovascular diseases.A large number of evidence has proved that TyG index can predict the risk of ischemic stroke.TyG index is independently associated with the adverse clinical outcomes of ischemic stroke,which can aggravate the deterioration of the nervous system during hospitalization and cause the recurrence of ischemic stroke.Individuals with a high TyG index are more likely to develop cerebrovascular diseases,and a potential linear dose-response relationship is observed.This article systematically summarizes the evidence for the association between TyG index and stroke and discusses the value of TyG in optimizing the risk stratification of ischemic stroke.