事件相关电位P300在帕金森病认知功能障碍中的研究进展

Research progress on event-related potential P300 in cognitive dysfunction in Parkinson disease

帕金森病(Parkinson disease,PD)是临床常见的神经系统退行性疾病。认知功能障碍严重影响PD患者的生活质量,增加家庭负担。目前临床上尚无相关的生物标志物协助PD认知功能障碍早期诊断。事件相关电位P300是一项灵敏的电生理指标,可以检测PD患者疾病初期隐匿的认知能力下降。本文就P300在PD患者认知障碍中的诊断价值及临床应用进行综述。

Parkinson disease(PD)is a common neurodegenerative disease.Cognitive dysfunction seriously affects the quality of life of patients with PD,increasing their family burden.Currently,there are no clinically identified biomarkers to assist with the early diagnosis of cognitive impairment in patients with PD.Event-related potential P300 is a sensitive electrophysiological indicator to detect early insidious cognitive decline in PD.This article reviews the diagnostic value and clinical application of P300 for cognitive impairment in patients with PD.