S1PR1在胃癌组织中的表达及其临床意义

Expression and clinical significance of S1PR1 in gastric cancer tissues

目的:探讨1-磷酸神经鞘氨醇受体(sphingosine-1-phosphate receptor 1,S1PR1)在胃癌组织中的表达及其临床意义。方法:回顾性分析具有完整临床病理资料的胃癌患者328例,选用免疫组化方法检测S1PR1的表达,并分析其与胃癌临床病理特征和预后的关系。结果:S1PR1在临床Ⅰ+Ⅱ期组织中阳性率为55.3%,在临床Ⅲ+Ⅳ期组织中阳性率为70.2%,两者差异具有统计学意义(P<0.05),S1PR1与胃癌淋巴结转移、肿瘤最大径之间具有统计学差异(P<0.05),与患者年龄、性别、肿瘤分化程度、Lauren分型无统计学差异。S1PR1阳性表达者相比阴性表达者总生存期较短,差异具有统计学意义(P<0.05)。胃癌组织中S1PR1的表达明显高于癌旁组织(P<0.05)。结论:S1PR1与胃癌患者的临床分期及肿瘤淋巴结转移密切相关,S1PR1阳性表达与患者预后较差有关,这为未来胃癌的治疗提供了新的思路。

Objective:To investigate the expression of sphingosine-1-phosphate receptor 1(S1PR1) and its clinical significance in gastric cancer tissues.Methods:A retrospective analysis was conducted on 328 gastric cancer patients with complete clinicopathological data.The expression of S1PR1 was detected by immunohistochemistry and its relationship with the clinicopathological features and prognosis of gastric cancer was analyzed.Results:The positive rate of S1PR1 in clinical stage Ⅰ+Ⅱ tissues was 55.3%,while it was 70.2% in tissues from clinical stage Ⅲ+Ⅳ.The difference was statistically significant(P<0.05).There were statistically significant differences in S1PR1 expression between gastric cancer patients with lymph node metastasis and tumor size(P<0.05),but no statistically significant differences with age,gender,tumor differentiation,and Lauren classification.The overall survival time of S1PR1 positive expression patients was shorter than that of negative expression patients,and the difference was statistically significant(P<0.05).The expression of S1PR1 in gastric cancer tissues was significantly higher than that in adjacent tissues(P<0.05).Conclusion:The expression of S1PR1 is closely related to the clinical stage and lymph node metastasis of gastric cancer patients,and S1PR1 positive expression is associated with poor prognosis.These findings provide new insights for the future treatment of gastric cancer.