无症状脓尿与尿路上皮癌预后相关性的研究进展

Research progress on the correlation between asymptomatic pyuria and prognosis of urothelial cancer

炎症反应在肿瘤的发生、促进和发展中起着重要作用。无症状脓尿(asymptomatic pyuria,AP),被认为是反映泌尿系统炎症状态的指标,与尿路上皮癌(urothelial carcinoma,UC)的预后密切相关。近期研究表明,AP的变化影响肿瘤微环境和局部炎症反应,对UC的复发、治疗和疾病进展有预测作用。本文系统性梳理近年来关于AP的临界值、作用机制及其对上尿路上皮癌和膀胱癌预后价值的相关文献,评价AP作为一种有效的UC预后指标指导治疗策略的潜力。

The inflammation response plays an important role in the promotion,occurrence and development of cancers.Asymptomatic pyuria(AP),considered to be reflect the state of the urinary tract inflammation index,is closely related with the prognosis of urothelial carcinoma(UC).Recent researchs show that the changes of AP affect tumor microenvironment and local inflammatory reaction,which can be used to predict recurrence,treatment and disease progression of UC.In this paper,we systematically reviewed the relevant literatures on the critical value and mechanism of action of AP,as well as its prognostic value for upper tract urothelial carcinoma and bladder cancer in recent years,to evaluate the potential of AP as an effective prognostic indicator for UC therapy.