阿尔茨海默病脾虚痰饮病机探析

Exploration of the Pathogenesis of Spleen Deficiency and Phlegm Fluid in Alzheimer's Disease

脾虚痰饮是阿尔茨海默病(Alzheimer's disease,AD)的病机特征。根据AD患者不同年龄阶段机能衰退及其记忆、思维与认知障碍,与脾土功能之间的关系,结合历代医家对该病认识,提出脾虚是AD发病的始动原因,痰饮内生、神机失用是AD进展的重要环节,健脾化痰/饮是AD的基本治法,苓桂术甘汤为干预AD的代表方剂。

Spleen deficiency and phlegm fluid are the pathological characteristics of Alzheimer's disease(AD).Based on the functional decline and memory,thinking,and cognitive impairments of AD patients at different age stages,as well as the relationship with spleen soil function,combined with the understanding of previous medical experts on this disease,it is proposed that spleen deficiency is the initial cause of AD,the endogenous production of phlegm fluid and the loss of spiritual transformation activity are important links in the progression of AD.Strengthening the spleen and resolving phlegm fluid are the basic treatment methods for AD,and Linggui Zhugan Decoction is a representative formula for intervening AD.