黄连中生物碱类成分抗溃疡性结肠炎的作用机制研究进展

Recent Progress on the Actions and Mechanisms of Alkaloids from Coptis Chinensis on Ulcerative Colitis

黄连是一味常用中药,具有清热燥湿,泻火解毒等功效,其中的主要活性成分为小檗碱、药根碱、黄连碱、表小檗碱等生物碱。现代药理学研究表明,黄连具有抗菌、抗氧化、免疫调节等药理作用,广泛用于治疗细菌性痢疾、胃炎、溃疡性结肠炎等胃肠道疾病。近年来,含黄连的复方、黄连及其中的生物碱类成分在溃疡性结肠炎的治疗中取得一定进展。基于此,主要从抑制炎症反应、调节免疫失衡、肠道菌群-宿主互作调控以及维持肠黏膜屏障功能角度,系统分析和归纳黄连及其生物碱类成分的抗溃疡性结肠炎机制,从而为黄连及溃疡性结肠炎治疗药物的开发提供参考。

Coptis chinensis is a commonly used traditional Chinese medicine with the effects of clearing heat and drying dampness,purging fire for removing toxin.The main active ingredients are alkaloids,like berberine,jateorhizine,coptisine,epiberberine and some other alkaloids.Modern pharmacological studies have shown that Coptis chinensis possess antibacterial,antioxidant,immunomodulatory and other pharmacological effects,and is widely used in the treatment of bacterial dysentery,gastritis,ulcerative colitis and other gastrointestinal diseases.In recent years,compound formulas containing Coptis chinensis,Coptis chinensis extracts and the alkaloid components from Coptis chinensis have shown therapeutic potential in the treatment of ulcerative colitis.Based on this,this paper systematically analyses and summarizes the anti-ulcerative colitis mechanisms of Coptis chinensis and its alkaloid components from the perspectives of regulating inflammatory response,normalizing immune imbalance,regulating gut microbiota-host interactions,and maintaining the intestinal mucosal barrier integrity,so as to provide references for the development of Coptis chinensis and therapeutic drugs for ulcerative colitis.