2型糖尿病下肢血管病变腔内介入治疗联合西洛他唑治疗短期效果观察

Short term effect of endovascular interventional therapy combined with cilostazol in the treatment of lower extremity vascular diseases in type 2 diabetes

目的分析2型糖尿病下肢血管病变腔内介入治疗联合西洛他唑治疗的短期效果。方法选取60例2型糖尿病下肢血管病变患者,按随机对照1∶1原则分为2组,即对照组30例,观察组30例,对照组采用腔内介入治疗,观察组在对照组腔内介入治疗的基础上采用西洛他唑治疗,对比两组肢体恢复情况。结果观察组术后8周间歇性跛行评分为(0.72±0.18)分、肢体疼痛评分为(1.82±0.46)分,低于对照组的(1.64±0.25)分、(2.93±0.52)分,踝肱指数(1.30±0.18)高于对照组(1.08±0.15),经皮氧分压为(30.86±4.31)kPa,高于对照组的(25.85±4.29)kPa,下肢动脉的血流峰速、足背动脉搏动指数(DPAPI)高于对照组(P<0.05),观察组未出现下肢动脉再狭窄,再狭窄率低于对照组的6.67%。结论腔内介入治疗联合西洛他唑能改善2型糖尿病患者下肢血管病变、间歇性跛行及肢体疼痛感,增加踝肱指数,促进血液循环。

Objective Analysis of the short-term effect of endovascular interventional therapy combined with cilostazol in the treatment of lower extremity vascular diseases in type 2 diabetes.Methods Sixty patients with lower limb vascular disease of type 2 diabetes were selected and divided into two groups according to the principle of random control 1:1,30 cases in the control group and 30 cases in the observation group.The control group was treated with endovascular intervention and the observation group was treated with cilostazol on the basis of endovascular intervention.The limb recovery of the two groups was compared.Results The intermittent claudication score(0.72±0.18)and limb pain score(1.82±0.46)of the observation group were lower than those(1.64±0.25 and 2.93±0.52)in the control group at 8 weeks after surgery.The ankle pump index(1.30±0.18)was higher than that in the control group(1.08±0.15),and the percutaneous oxygen pressure(30.86±4.31)kPa was higher than that in the control group(25.85±4.29)kPa.The peak blood flow velocity of the lower limb arteries and the dorsal foot artery pulsation index(DPAPI)were higher than those in the control group(P<0.05).The observation group did not experience lower limb artery restenosis,and the restenosis rate was 6.67%.Conclusion Endovascular interventional therapy combined with Cilostazol can alleviate intermittent claudication and limb pain in type 2 diabetic patients with lower limb vascular disease,increase ankle pump index and promote blood circulation.