艾滋病抗病毒持续治疗的效果分析

Analysis on the efficacy of continuous antiviral treatment for AIDS

目的了解艾滋病抗病毒持续治疗的效果。方法收集6469例艾滋病患者的临床资料,所有患者均接受拉米夫定+富马酸替诺福韦二吡呋+依非韦伦抗病毒治疗,比较持续治疗与未持续治疗患者的疗效。结果6469例患者中持续治疗5913例,未持续治疗556例。持续治疗患者的疗效明显优于未持续治疗者(P<0.01);持续治疗后不同时间段患者的谷丙转氨酶、尿素氮、谷草转氨酶、总蛋白、肌酐、白蛋白、总胆红素、直接胆红素差异有统计学意义(P<0.01)。结论持续抗病毒治疗可以有效控制艾滋病患者病情的发展,但同时也会引起肝肾功能指标的变化,需临床医生注意和及时处理。

Objective To explore the efficacy of continuous antiviral treatment for AIDS.Methods Clinical data of 6469 AIDS patients were collected.All the patients have received antiviral treatment with lamivudine,tenofovir disoproxil fumarate and efavirenz.The treatment effect was compared between the patients receiving continuous treatment and those receiving no continuous treatment.Results Among the 6469 patients,5913 received continuous treatment and 556 received no continuous treatment.The patients receiving continuous treatment had a better therapeutic effect(P<0.01).There were significant differences in TP,ALT,BUN,AST,Cr,ALB,TBIL and DBIL at different time periods after continuous treatment(P<0.01).Conclusion Continuous antiviral treatment for AIDS patients can control the progression of the disease and improve the patients’condition,but it can also cause changes in hepatic and renal indicators,requiring timely clinical response.