复方太子参颗粒治疗儿童缺铁性贫血的临床疗效及预后影响研究

Clinical efficacy and prognostic impact of compound Taizishen granules in the treatment of iron deficiency anemia in children

目目的:探讨复方太子参颗粒治疗儿童缺铁性贫血的临床疗效及对预后效应。方法:选择某医院收治的195例缺铁性贫血患儿作为研究对象,据治疗方式分餐前组(n=65),餐后组(n=65)和对照组(n=65)。对照组右旋糖酐铁口服液治疗,研究组患者分餐前、餐后服用复方太子参颗粒治疗。比较三组疗效及症状消失时间,记录治疗前后血红蛋白(Hb)、平均红细胞血红蛋白含量(MCH)、平均红细胞体积(MCV)及智力发育指数(MDI)、精神运动发育商(DQ)变化,并统计三组患儿不良反应。结果:餐前组总有效率96.92%和餐后组总有效率92.31%均高于对照组76.92%(P<0.05);餐前组、餐后组上述症状消失时间与对照组比较有统计学意义(P<0.05);三组治疗前的Hb、MCV、MCH指标均水平均相近(P>0.05);治疗后,餐前组、餐后组的Hb、MCV、MCH指标均升高,且明显高于对照组(P<0.05);治疗前,三组的MDI、DQ评分均相近(P>0.05);治疗后,餐前组、餐后组的MDI、DQ评分均升高,且明显高于对照组(P<0.05);餐前组、餐后组不良反应发生率为1.54%、3.08%均低于对照组的16.92%(P<0.05)。结论:复方太子参颗粒不管是餐前还是餐后服用均可有效缓解患儿的临床症状及相关贫血指标,促进患儿生长发育,且安全性高。

Objective:Toexplore clinical efficacy and prognostic of compound Taizishen granules in treatment of children's iron deficiency anemia.Methods:According to treatment methods,195 children with iron deficiency anemia were divided into pre-meal,post-meal and control group,and received treatment with compound Taizishen granules and iron dextran oral solution,respevtively.Efficacy,symptom disappearance time,changes in hemoglobin(Hb),mean corpuscular hemoglobin content(MCH),mean corpuscular volume(MCV),intellectual development index(MDI),psychomotor development quotient(DQ)and adverse reactions of three groups were compared and recorded.Results:Compared with the control group,total effective rate in pre-and post-meal groups were higher,the incidence of adverse reactions was lower,and symptom disappeared more quickly(P<0.05).After treatment,levels of Hb,MCV,MCH indexes,MDI and DQ scores in pre-and post-meal groups were significantly higher than those in control(P<0.05).Conclusion:Compound Taizishen granules can safely and effectively improve symptoms of iron deficiency anemia and promote growth and development of children.