红萸饮治疗放射性肠炎临床研究

Clinical Study on Hongyu Decoction(红萸饮)in Treatment of Radiation Enteritis

目的:观察红萸饮对放射性肠炎患者临床症状及生活质量的影响。方法:将68例患者随机分为观察组和对照组各34例,两组均有2例脱落,各余32例。观察组采用红萸饮口服治疗30 d,对照组采用柳氮磺胺吡啶(SASP)联合诺氟沙星(NOR)口服治疗,SASP口服30 d,NOR口服7 d,观察比较两组患者症状积分、肠鸣音次数、直肠黏膜积分、生活质量评分、不良反应情况及总有效率。结果:治疗过程中,两组患者均未发生严重不良反应;治疗后,两组上述观察指标均较治疗前改善(P<0.05),且除腹痛积分外,观察组其他症状积分及肠鸣音次数、直肠黏膜积分均低于对照组(P<0.05),生活质量评分高于对照组(P<0.05);总有效率为观察组87.5%,对照组68.8%,两组疗效比较,差异无统计学意义(P>0.05)。结论:红萸饮口服更能缓解放射性肠炎患者便血、里急后重、大便次数增多等症状,提高生活质量。

Objective:To observe the effect of Hongyu Decoction(红萸饮)on clinical symptoms and quality of life of patients with radiation enteritis.Methods:Total 68 patients were randomly divided into the observation group and the control group,with 34 cases in each group,2 cases dropped out in each group,with 32 cases in each group.The observation group was given oral administration of Hongyu Decoction for 30 days and the control group was given sulfasalazine(SASP)combined with norfloxacin(NOR)orally,SASP was for 30 days and NOR was for 7 days.The symptom score,frequency of bowel sound,rectal mucosa score,quality of life score,adverse symptoms and total effective rate of the two groups were observed and compared.Results:During the treatment,no serious adverse reactions occurred in both groups.After treatment,the above observation indexes in both groups were improved compared with those before treatment(P<0.05),and except for abdominal pain scores,the scores of other symptoms,the number of intestinal sounds and rectal mucosa score in the observation group were lower than those in the control group(P<0.05),and the score of quality of life in the observation group was higher than that in the control group(P<0.05).The total effective rate was 87.5%in the observation group and 68.8%in the control group.There was no statistically significant difference between the two groups(P>0.05).Conclusion:Oral administration of Hongyu Decoction can alleviate the symptoms of hematostoecium,posterior tenor and increased frequency of stool in patients with radiation enteritis,and improve the quality of life.