藏茶对高脂血症患者降脂减肥疗效的临床研究

Clinical Study on the Lipid-lowering Effect of Tibetan Tea on Patients with Hyperlipidemia

为观察藏茶联合阿托伐他汀钙治疗高脂血症的疗效,将80例高脂血症患者随机分为试验组和对照组各40例,试验组予藏茶联合阿托伐他汀钙治疗,对照组予单纯阿托伐他汀钙治疗,观察两组患者治疗12周后血脂、人体成分检测指标[体质量、体脂百分比、身体质量指数(BMI)、腰围、内脏脂肪面积]、血清氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]及胰岛素抵抗监测指标[血清胰岛素、血清游离脂肪酸(FFA)、胰岛素抵抗指数(HOMA-IR)]变化情况。结果发现,与治疗前相比,治疗后试验组体质量、BMI、体脂百分比、腰围、内脏脂肪面积、HOMA-IR、血清FFA、MDA等均较治疗前极显著降低,血清SOD极显著上升。与对照组相比,治疗后试验组体脂百分比极显著降低,体质量、腰围、内脏脂肪面积、血清FFA、MDA等均有显著降低,血清SOD显著上升。临床试验表明,藏茶联合阿托伐他汀钙治疗高脂血症能更加有效地降低血脂,减少内脏脂肪,改善机体胰岛素抵抗及氧化应激水平。

To observe the efficacy and safety of Tibetan tea combined with atorvastatin calcium in the treatment of hyperlipidemia,80 patients with hyperlipidemia were randomly divided into experimental group and control group to explore the fat and weight reducing mechanism of Tibetan tea.The experimental group was treated with Tibetan tea combined with atorvastatin calcium and the control group was treated with atorvastatin calcium alone.After 12 weeks of treatment,the blood lipid,body composition index[body weight,body fat percentage,body mass index(BMI),waist circumference,visceral fat area],serum oxidative stress index[superoxide dismutase(SOD),malondialdehyde(MDA)]and insulin resistance monitoring index[serum insulin,serum free fatty acid(FFA)],and pancreatic islet in 2 groups were measured.The change of hormone resistance index(HOMA-IR)and the occurrence of adverse reactions were recorded.The lipid-lowering effect of experimental group was significantly better than that of control group.After treatment,the body weight,BMI,body fat percentage,waist circumference,visceral fat area,HOMA-IR,serum FFA and MDA of the experimental group were all decreased compared with those before treatment,while serum SOD was significantly increased compared with that before treatment.After treatment,the body weight,body fat percentage,waist circumference,visceral fat area,serum FFA and MDA of the experimental group were significantly decreased compared with those of the control group,and serum SOD was significantly increased.Tibetan tea combined with atorvastatin calcium in the treatment of hyperlipidemia could more effectively lower blood lipids,reduce visceral fat,and improve insulin resistance and oxidative stress level in the body.