血小板相关肿瘤微环境在卵巢癌中的研究进展

Research Progress on Roles of Platelet-Associated Tumor Microenvironment in Ovarian Cancer

血小板是肿瘤微环境的重要成分之一,能够通过参与卵巢癌微环境、促进肿瘤血管生成和介导肿瘤免疫逃逸,促进卵巢癌的生长和转移。随着肿瘤微环境的动态变化,血小板的数量、体积也发生相应改变。血小板相关的生物标志物具有早期诊断及监测肿瘤状态的巨大潜力。基于血小板在卵巢癌进展中的重要作用,使用抗血小板药物和相应的靶向药物是一种新的治疗策略。全文聚焦于血小板相关肿瘤微环境在卵巢癌的作用,在总结作用机制的基础上,对血小板相关的生物标志物和抗血小板及靶向治疗进行阐述,旨在为卵巢癌的治疗提供新策略与方向。

Platelets are one of the important components of the tumor microenvironment,which can promote the tumor cell growth and metastasis,induce angiogenesis and mediate immune escape of ovarian cancer.The number and volume of platelets are changed dynamically with the changes of the tumor microenvironment,suggesting that platelet-related biomarkers may have potential for early diagnosis and monitoring of tumor status,and the antiplatelet and platelet-targeted drugs might be a new therapeutic strategy for ovarian cancer.This paper reviews the role of platelet-related tumor microenvironment in ovarian cancer,and elaborates platelet-related biomarkers,and antiplatelet and targeted therapy of ovarian cancer,aiming to provide new directions for clinical management of ovarian cancer.