颗粒物对动物肠-肺轴的影响及缓解策略

Effects of Particulate Matter on Gut-Lung Axis in Animals and Mitigation Strategies

畜禽舍内的颗粒物(PM)严重损害动物和工作人员的呼吸系统,且粒径越小,危害越大。颗粒物可破坏肺部组织结构,诱导肺部炎症损伤,改变肺部菌群组成。颗粒物也会导致肠道菌群紊乱,增加肠道通透性,造成肠道菌群容易移位或肠源性代谢产物通过肠-肺轴影响肺脏损伤的发展。降低畜禽舍内颗粒物的危害可以通过安装过滤系统、通风、空气电离等物理方法,也可以通过饲料加工和添加绿色添加剂的营养调控方法。本文主要综述颗粒物对动物肠-肺轴的影响,并从物理方法、饲料加工和营养调控方法等方面来探讨颗粒物对动物影响的缓解策略,以期寻找有效的缓解颗粒物影响动物健康的措施。

Particulate matter(PM)in livestock and poultry houses severely damages the respiratory system of animals and workers,and the smaller the particle size,the greater the harm.Particulate matter damages the lung tissue structure,induces lung inflammation and damage,and changes the composition of lung microbiota.In addition,particulate matter can also lead to gut microbiota disorder,increase intestinal permeability,resulting in gut microbiota to shift easily or gut derived metabolites affecting the development of lung injury through the gut-lung axis.Reducing the harm of particulate matter in livestock and poultry houses can be achieved through installing filtration systems,ventilation and air ionization,as well as feed processing and adding green additives.This article mainly reviews the impact of particulate matter on the gut-lung axis of animals,and explores the mitigation strategies of particulate matter on animal health such as physical methods,feed processing and nutritional regulation methods,in order to find effective measures to alleviate the impact of particulate matter on animal health.