基于线粒体功能障碍探讨中医药治疗脓毒性心肌病的研究思路

Study on the treatment of sepsis-induced cardiomyopathy with traditional Chinese medicine based on mitochondrial dysfunction

脓毒性心肌病(SIC)是导致脓毒症患者不良预后的重要原因.作为能量合成的关键细胞器,线粒体损伤导致的心肌能量代谢障碍成为SIC的核心病理生理机制.中医药治疗对于改善脓毒症患者心功能、提高疗效有重要意义.现从线粒体动力学、抗氧化应激损伤、线粒体生物合成、线粒体自噬等方面阐释脓毒症时心肌细胞线粒体功能障碍的病理生理机制和中医药以改善线粒体动力学、线粒体生物合成、线粒体自噬、线粒体抗氧化应激损伤为作用靶点的中药单体和复方减轻心肌损伤的作用机制进行综述,探索中医药治疗SIC的药效学物质基础,为SIC的中医药治疗拓展新的思路.

Sepsis-induced cardiomyopathy(SIC)is an important cause of poor prognosis in patients with sepsis.As a key organelle for energy synthesis,mitochondrial damage leading to myocardial energy metabolism disorders has become the core pathophysiological mechanism of SIC.Traditional Chinese medicine treatment is of great significance for improving cardiac function and improving therapeutic effects in patients with sepsis.This article reviews the pathological and physiological mechanisms of mitochondrial dysfunction in myocardial cells during sepsis from the perspectives of mitochondrial dynamics,antioxidant stress damage,mitochondrial biosynthesis,and mitophagy,as well as the protective mechanisms of traditional Chinese medicine targeting the improvement of mitochondrial dynamics,mitochondrial biosynthesis,mitophagy,and mitochondrial antioxidant stress damage to alleviate myocardial injury.Explore the pharmacodynamic material basis of Traditional Chinese medicine for treating SIC,and expand new ideas for the treatment of SIC with traditional Chinese medicine.