中药活性成分防治缺血性心脏病作用机制研究进展

Research progress on the mechanism of active ingredients of traditional Chinese medicine in preventing ischemic heart disease

缺血性心脏病(IHD)是由于冠脉循环供血改变引起冠脉血流和心肌需求之间不对等而导致心肌细胞受损的一种多发性疾病。中药活性成分具有来源广泛、成分明确、多靶点的优势。为明确中药活性成分防治IHD病理机制,归纳了中药活性成分在防治IHD研究中几个关键环节(氧化应激、细胞凋亡及其自噬、炎症反应)研究的主要进展,分析了中药活性成分抗心肌细胞损伤和死亡的治疗策略及作用机制,在此基础上对中药活性成分防治IHD的研究前景进行了展望,以期为中医药防治IHD提供科学依据。

Ischemic heart disease(IHD)is a serious and multiple disease that endangers human health due to myocardial cell damage Anhui Medical and Pharmaceutical Journal 2024 Jan,28(1)caused by unequal coronary blood flow and myocardial demand due to changes in coronary circulation blood supply.The active ingredi⁃ents of traditional Chinese medicine(TCM)have the advantages of wide sources,clear components and multiple targets.To clarify the pathological mechanism of active components of TCM in the prevention and treatment of IHD,we summarize the main progress of re⁃search on several key aspects(oxidative stress,apoptosis,autophagy,and inflammation)of active components of TCM in the study of IHD and analyze the therapeutic strategies and mechanisms of active components of TCM in the prevention and treatment of IHD against myocardial cell injury and death.On the basis of this study,the research prospects of the active ingredients of TCM against IHD are analyzed to provide a scientific basis for the prevention and treatment of IHD by TCM.