嵌合抗原受体T细胞免疫治疗所致细胞因子释放综合征相关细胞因子的研究进展

Research Progress in Cytokine Release Syndrome-Related Cytokines Caused by CAR-T Cell Therapy

嵌合抗原受体T细胞免疫治疗(CAR-T)可导致细胞因子释放综合征(CRS),且多种细胞因子在CRS发生发展中起着重要作用。其中IFN-γ、IL-6是CRS发生的重要驱动因子,IFN-γ、sVCAM-1和Ang-2/Ang-1升高对CRS的发生有预测价值,IFN-γ、IL-6、CRP、GM-CSF、MCP-1等与CRS严重程度相关。阻断IFN-γ、GM-CSF可能可减少CRS的发生。文章明确CAR-T所致CRS相关细胞因子在CRS发生、发展中的角色定位,以期为诊断评估、动态监测、及时处理CRS提供依据。

Chimeric antigen receptor(CAR) immunotherapy can result in cytokine release syndrome(CRS),and a variety of cytokines play an important role in the occurrence and development of CRS.Interferon-γ(IFN-γ) and interleukin-6(IL-6)are important drivers for the occurrence of CRS.The increase in IFN-γ,soluble vascular cell adhesion molecule-1 and angiotensin-Ⅱ/angiotensin-I may predict the occurrence of CRS,and the concentrations of IFN-γ,IL-6,C-reactive protein,granulocyte-macrophage colony-stimulating factor(GM-CSF),monocyte chemoattractant protein-1,etc.are related to the severity of CRS.Blocking IFN-γ and GM-CSF may reduce the occurrence of CRS.This article clarifies the role of cytokines related to CAR-T cell therapy caused CRS in the occurrence and development of CRS,and provides a basis for diagnostic evaluation,dynamic monitoring and timely treatment of CRS.