海口市幽门螺杆菌的1年复发率及影响因素分析

Analysis of one-year recurrence rate of Helicobacter pylori infection and its influencing factors in Haikou city

目的幽门螺杆菌(Helicobacter pylori,H.pylori)感染根除后仍有复发的可能,各国、各地区的复发率也不一样。本研究旨在测定海口市人群H.pylori感染首次根除成功后1年内复发情况,并分析其可能的影响因素。方法回顾性分析H.pylori感染并首次根除成功并完成随访1年的652例患者的临床资料,于2022年1月至2023年10月在海南医学院第二附属医院就诊,记录记录H.pylori根除后的复发情况,H.pylori 1年内复发的影响因素采用单因素分析和多因素逻辑回归分析。结果共20例H.pylori感染复发,1年后复发率为3.06%。单因素分析表明,接触其他H.pylori感染者、餐馆卫生条件差、外出就餐频率高、收入水平、职业、性别、年龄与H.pylori感染的复发有相关性。多因素分析显示,H.pylori复发常见于女性(OR=5.734,95%CI=1.362~24.148,P=0.017),餐馆卫生条件差(OR=0.088,95%CI=0.017~0.452,P=0.004),频繁外出聚餐(OR=4.745,95%CI=1.463~15.391,P=0.009)和接触其他H.pylor i感染者(OR=12.724,95%CI=4.001~40.470,P=0.034)是H.pylori复发的独立危险因素。结论海口市H.pylori感染人群根除治疗后1年复发率相对较高。复发常见于女性,频繁外出就餐、餐馆卫生条件差和接触其他H.pylori感染者是复发的独立危险因素。

Objective Helicobacter pylori(H.pylori)is a gram negative bacterium that has been confirmed to be implanted in the human gastric mucosa.Its infection is closely related to various digestive system diseases,and there is still a possibility of recurrence after eradication,with significant differences in recurrence rates among different countries and regions.The purpose of this study is to determine the recurrence rate of H.pylori within one year after the first successful eradication of H.pylori infection in Haikou City,and analyze its possible influencing factors.Methods A retrospective analysis was conducted on the clinical data of 652 patients diagnosed with H.pylori infection and followed up at the Second Affiliated Hospital of Hainan Medical University from January 2022 to October 2023.Univariate analysis and multivariate logistic regression analysis were used to explore the influencing factors of H.pylori recurrence.Results Among 652 patients,20 had H.pylori infection recurrence,with a recurrence rate of 3.06%one year later.Univariate analysis showed that exposure to other H.pylori infected individuals,poor restaurant hygiene,high frequency of dining out,income level,occupation,gender,and age were correlated with the recurrence of H.pylori infection.Multivariate analysis showed that H.pylori recurrence was common in females(OR=5.734,95%CI=1.362-24.448,P=0.017),poor restaurant hygiene conditions(OR=0.088,95%CI=0.017-0.452,P=0.004),frequent outings to gatherings(OR=4.745,95%CI=1.463-15.391,P=0.009),and exposure to other H.pylori infected individuals(OR=12.724,95%CI=4.001-40.470,P=0.034)were independent risk factors for H.pylori recurrence.Conclusion The recurrence rate of H.pylori after eradication treatment in Haikou City,Hainan Province is relatively high.Women,frequent dining out,poor restaurant hygiene,and exposure to other H.pylori-infected patients are risk factors for the recurrence of H.pylori.