平均红细胞体积与腹主动脉钙化评分及严重程度的关系

Correlation between mean corpuscular volume and abdominal aortic calcification score and severity

目的探讨平均红细胞体积(MCV)与腹主动脉钙化(AAC)评分及其严重程度的关系。方法腹主动脉钙化人群及相关实验室数据均来自美国国家健康与营养调查数据库,由该数据库数据采集人员采集数据,采用双能X线吸收仪扫描参与者腰椎。本研究共纳入3056名参与者,并用Kauppila评分系统衡量腹主动脉钙化程度。Kauppila=0、0<Kauppila<6、Kauppila≥6分别定义为无腹主动脉钙化、轻-中度腹主动脉钙化及重度腹主动脉钙化。根据MCV水平的四分位数将参与者分为Q1、Q2、Q3、Q4组,采用加权的Pearson相关性分析、线性回归分析及多分类Logistic回归方法分析MCV水平与AAC评分及严重程度的关系。结果参与者根据MCV四分位评分分组:Q1组762例,Q2组765例,Q3组759例,Q4组770例。从Q1组到Q4组,AAC评分逐渐增加,且轻-中度AAC和重度AAC患者比例逐渐增加,四组间差异均有统计学意义(P<0.05)。Person相关分析结果显示,MCV水平与AAC评分呈正相关(r=0.083,P<0.001);线性回归分析显示,MCV值每增加1 fl,AAC评分增加0.048(95%CI:0.028~0.069,P<0.001);多分类Logistic回归分析显示,调整性别、年龄等多种危险因素后,MCV每增加1 fl,发生轻-中度AAC的可能性增加0.47%(OR 1.0047,95%CI:1.0046~1.0047,P<0.001),发生重度AAC的可能性增加3.06%(OR 1.0306,95%CI:1.0305~1.0307,P<0.001)。结论MCV高低与AAC评分呈显著正相关关系,且为严重AAC的独立危险因素。

Objective To investigate the relationship between the mean corpuscular volume(MCV)and the abdominal aortic calcification(AAC)score and the severity of AAC.Methods The abdominal aortic calcification population and the related laboratory data were collected from the National Health and Nutrition Examination Survey database by data collectors who used dual-energy X-ray absorptiometry to scan participants’lumbar vertebra.A total of 3056 participants were included in the study and the degree of abdominal aortic calcification was measured using the Kauppila score system.Kauppila=0,0<Kauppila<6,and Kauppila≥6 were defined as no abdominal aortic calcification,mild to moderate abdominal aortic calcification,and severe abdominal aortic calcification,respectively.Participants were divided into Q1 group,Q2 group,Q3 group and Q4 group according to the MCV quartile.Weighted person correlation analysis,linear regression analysis and multinomial Logistic regression were used to analyze the relationships between MCV and AAC score and AAC severity.Results Participants were divided into four groups based on the MCV quartile,there were 762 cases in Q1 group,765 cases in Q2 group,759 cases in Q3 group,and 770 cases in Q4 group.AAC score,and the proportions of patients with mild-moderate AAC and severe AAC gradually increased from Q1 group to Q4 group(P<0.05).Person correlation analysis showed that MCV was positively correlated with AAC score(r=0.083,P<0.001).Linear regression analysis showed that AAC score increased by 0.048 for each 1 fl increase of MCV(95%CI 0.028-0.069,P<0.001).Multinomial Logistic regression analysis showed that after adjusting for multiple risk factors such as sex and age,the probability of mild-moderate AAC increased by 0.47%for every 1 fl increase of MCV(OR=1.0047,95%CI 1.0046-1.0047,P<0.001)and the likelihood of severe AAC increased by 3.06%(OR=1.0306,95%CI 1.0305-1.0307,P<0.001).Conclusion MCV level is positively correlated with AAC score,and it is an independent risk factor for severe AAC.