摘要
目的建立大黄灵脾颗粒剂的质量标准。方法采用高效液相色谱法(HPLC)对大黄灵脾颗粒剂中的淫羊藿苷、丹酚酸B分别进行含量测定。结果淫羊藿苷和丹酚酸B进样量分别在0.038~7.672µg(r=0.9998)和0.275~4.216µg(r=0.9999)范围内,与峰面积线性关系良好,平均加样回收率分别为98.5%(RSD=1.9%)和97.7%(RSD=1.9%)。结论HPLC简便、准确、可靠、重现性好,可有效控制大黄灵脾颗粒剂的质量。
Objective To develop a quantitative method for the quality control of Dahuang Lingpi granules.Methods HPLC methods were established for the determination of icariin and salvianolic acid B in granules.Results In the range of 0.03836-7.6720µg(r=0.998)and 0.2748-4.2160µg(r=0.999)separately,the injection quantity of icariin and salvianolic acid B had good linear relationship with peak area.The average recovery rate were 98.5%(RSD=1.9%)and 97.7%(RSD=1.9%)for the two index components.Conclu-sion The method is simple,accurate and reliable with good reproducibility,which could be used for the quality control of Dahuang Lingpi granules.
作者
陈群力
姚申
吴飞
CHEN Qunli;YAO Shen;WU Fei(Department of Pharmacy,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China;Department of General Outpatient,Sanlin Community Health Service Center of Shanghai Pudong New District,Shanghai 200124,China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国中医药现代远程教育》
2024年第3期114-117,共4页
Chinese Medicine Modern Distance Education of China
基金
上海市教育委员会“教师专业发展工程”上海高校教师培养计划项目[No.沪教委人〔2023〕37号,A1-2601-23-311007]。
