当归饮子联合卡泊三醇治疗血燥型银屑病的临床疗效分析

Clinical Effect of Angelica Decoction Combined with Carpotriol in the Treatment of Psoriasis with Blood Desiccant

目的探讨当归饮子联合卡泊三醇治疗血燥型银屑病的临床疗效。方法选择2021年8月—2023年5月泰安市中医二院收治的血燥型银屑病者80例为研究对象,按照随机数表法分为两组,各40例。对照组所有入组者均使用卡泊三醇软膏局部涂抹,观察组联合使用当归饮子口服,比较两组治疗期间皮损面积及严重程度指数(Psoriasis Area and Severity Index,PASI)评分变化情况,比较两组治疗1个月后中医证候评分变化,统计两组治疗前后炎症指标[C-反应蛋白(C-reactive protein,CRP)和血沉],统计两组治疗期间出现的并发症或临床不适情况。结果治疗1周后及1个月后,观察组PASI评分低于对照组,差异有统计学意义(P<0.05)。治疗1个月后,观察组中医证候评分显著低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CRP和血沉水平分别为(8.1±0.8)mg/L、(18.1±2.1)mm/h,低于治疗前及对照组,差异有统计学意义(P<0.05)。观察组严重疼痛、肝功能受损、尿常规异常和局部感染的总发生率(2.5%)低于对照组,差异有统计学意义(χ^(2)=5.600,P<0.05)。结论当归饮子治疗血燥型银屑病者,可快速减少皮损面积,改善患者临床不适,降低机体炎症反应,且安全性高。

Objective To explore the clinical effect of angelica decoction combined with carpotriol in the treatment of psoriasis with blood desiccant.Methods A total of 80 patients with psoriasis with blood desiccant admitted to the Second Hospital of Traditional Chinese Medicine of Tai'an City from August 2021 to May 2023 were selected as the study objects,and were divided into two groups according to random number table method,with 40 cases in each group.All participants in the control group were applied with carpotriol ointment,and the observation group was combined with angelica decoction for oral administration.The changes of Psoriasis Area and Severity Index(PASI)scores between the two groups during treatment were compared.The changes of TCM syndrome scores were compared between the two groups after 1 month of treatment,and the inflammatory indicators[C-reactive protein(CRP)and erythrocyte sedimentation rate]were counted before and after treatment between the two groups,and the complications or clinical discomfort occurred during treatment between the two groups were counted.Results After 1 week and 1 month of treatment,PASI score of observation group was lower than that of control group,and the difference was statistically significant(P<0.05).After 1 month of treatment,the TCM syndrome score of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,CRP and SBR levels in observation group were(8.1±0.8)mg/L and(18.1±2.1)mm/h,respectively,lower than before treatment and control group,the difference were statistically significant(P<0.05).The total incidence rate of severe pain,liver function impairment,abnormal urine routine and local infection in the observation group(2.5%)was lower than that in the control group,and the difference was statistically significant(χ^(2)=5.600,P<0.05).Conclusion Angelica decoction in the treatment of psoriasis can rapidly reduce the area of skin lesions,improve the clinical discomfort of patients,reduce the inflammatory response of the body,and high safety.