2011—2022年苍南县孕产妇乙型肝炎病毒携带情况调查

Hepatitis B virus carriage among pregnant and lying-in women in Cangnan County from 2011 to 2022

目的了解2011—2022年浙江省苍南县孕产妇乙型肝炎病毒(HBV)携带情况及其影响因素,为指导HBV携带者妊娠期保健提供依据。方法以苍南县第三人民医院2011年1月—2022年7月住院分娩的34403名孕产妇为研究对象,收集孕产妇的人口学信息、HBV携带情况和妊娠结局等临床资料。分析苍南县孕产妇HBV携带率,并采用多因素logistic回归模型分析HBV携带的影响因素。结果收集34403名孕产妇资料,年龄M(QR)为27.00(7.00)岁。流动人口8118人,占23.60%。HBV携带者1182例,携带率为3.44%;2011—2014年、2015—2018年和2019—2022年携带率分别为1.59%、4.08%和6.86%,呈上升趋势(P<0.05)。多因素logistic回归分析结果显示,预产年龄(20~<25岁,OR=1.832,95%CI:1.037~3.235;25~<30岁,OR=2.404,95%CI:1.372~4.214;30~<35岁,OR=2.914,95%CI:1.656~5.129;35~<40岁,OR=3.116,95%CI:1.741~5.576;≥40岁,OR=2.358,95%CI:1.145~4.858)、流动人口(OR=0.670,95%CI:0.574~0.782)、前胎剖宫产术后瘢痕子宫(OR=1.228,95%CI:1.076~1.521)、分娩年份(2015—2018年,OR=2.504,95%CI:2.143~2.926;2019—2022年,OR=4.425,95%CI:3.779~5.182)是孕产妇HBV携带的影响因素。结论2011—2022年苍南县孕产妇HBV携带率呈上升趋势,预产年龄、流动人口、分娩年份和前胎剖宫产术后瘢痕子宫是孕产妇HBV携带的影响因素。

Objective To investigate the prevalence of hepatitis B virus(HBV)carriage among pregnant and lying-in women in Cangnan County,Zhejiang Province from 2011 to 2022 and identify the influencing factors,so as to provide insights into the guidance of healthcare among HBV carriers during pregnancy.Methods A total of 34403 women delivered in The Third People's Hospital of Cangnan County from January 2011 to July 2022 were enrolled,and their demographics,HBV carriage and pregnant outcomes were collected.The prevalence of HBV carriage was analyzed among pregnant and lying-in women,and factors affecting HBV carriage were identified using a multivariable logistic regression model.Results A total of 34403 pregnant and lying-in women were enrolled,with a median age of 27.00(interquartile range,7.00)years,and including 8118 floating populations(23.60%).The overall prevalence of HBV carriage was 3.44%,and the prevalence of HBV carriage was 1.59%from 2011 to 2014,4.08%from 2015 to 2018 and 6.86%from 2019 to 2022,appearing a tendency towards a rise(P<0.05).Multivariable logistic regression analysis identified estimated age of delivery(20-24 years,OR=1.832,95%CI:1.037-3.235;25-29 years,OR=2.404,95%CI:1.372-4.214;30-34 years,OR=2.914,95%CI:1.656-5.129;35-39 years,OR=3.116,95%CI:1.741-5.576;40 years and older,OR=2.358,95%CI:1.145-4.858),floating population(OR=0.670,95%CI:0.574-0.782),scarred uterus after cesarean section(OR=1.228,95%CI:1.076-1.521)and year of delivery(from 2015 to 2018,OR=2.504,95%CI:2.143-2.926;from 2019 to 2022,OR=4.425,95%CI:3.779-5.182)as factors affecting HBV carriage among pregnant and lying-in women.Conclusions The prevalence of HBV carriage rate appeared a tendency towards a rise among pregnant and lying-in women in Cangnan County from 2011 to 2022.Estimated age of delivery,floating population,year of delivery and scarred uterus after cesarean section are factors affecting HBV carriage.