番泻叶治疗便秘作用机制的研究进展

Research progress on mechanism of senna leaf in treating constipation

便秘在我国是最常见的胃肠道症状之一,据统计,我国便秘总体患病率高达3%~11%。番泻叶(Senna)以其价格低廉、见效快等优势成为全世界应用最广泛的刺激性泻剂之一,其通便作用机制主要为调节肠神经系统、影响胃肠平滑肌、影响Cajal间质细胞、调节水通道蛋白以及干预肠道微生态等。本文通过搜集近5年的中英文文献资料,从番泻叶治疗便秘的临床研究、作用机制、不良反应等方面进展作一综述,以期为其相关制剂的研发提供理论依据。

Constipation is one of the most common gastrointestinal symptoms in our country.According to statistics,the overall prevalence of constipation is as high as 3%~11%.Senna leaf has become one of the most widely used stimulant copragogue in the world due to its advantages of low price and quick effect.Its laxative mechanism mainly includes regulating enteric nervous system,affecting gastrointestinal smooth muscle,affecting Cajal interstitial cells,regulating aquaporin and interfering with intestinal microecology.In this review,the mechanism,clinical studies and adverse reactions of senna leaf in the treatment of constipation are reviewed by collecting Chinese and English literature in recent 5 years,in order to provide theoretical basis for the research and development of related preparations.