血清LDH、VEGF-C与胃癌临床病理特征及患者预后的关系

Relationship Between Serum LDH,VEGF-C and Clinicopathologic Features and Prognosis of Patients with Gastric Cancer

目的探讨血清LDH、VEGF-C与胃癌临床病理特征及患者预后的关系。方法收集胃癌患者68例。采用酶联免疫吸附试验检测血清LDH、VEGF-C水平。统计两组血清LDH、VEGF-C水平,分析血清LDH、VEGF-C水平与胃癌临床病理特征的关系,单因素及多因素分析影响胃癌患者预后因素。结果血清LDH、VEGF-C水平与胃癌分化程度、TNM分期、淋巴结转移、肿瘤直径有关,与性别、年龄均无关。单因素分析显示,肿瘤分化程度、TNM分期、淋巴结转移、LDH、VEGF-C水平均为胃癌患者不良预后影响因素(P<0.05)。多因素分析显示,低分化、TNM分期Ⅲ~Ⅳ期、淋巴结转移、LDH、VEGF-C水平均为胃癌患者不良预后影响因素(P<0.05)。血清LDH联合VEGF-C对胃癌具有较高诊断价值,AUC为0.877,95%CI为0.783~0.925,灵敏度为80.89%,特异度为95.18%。结论胃癌患者血清LDH、VEGF-C水平较高,且与胃癌分化程度、TNM分期、淋巴结转移、肿瘤直径有关,且是影响患者预后的独立危险因素,临床可通过监测LDH、VEGF-C水平预测患者预后。

Objective To investigate the relationship between serum LDH,VEGF-C and clinicopathologic features and prognosis of patients with gastric cancer.Methods 68 patients with gastric cancer were collected.Serum LDH and VEGF-C levels were detected by enzyme-linked immunosorbent assay.Serum LDH and VEGF-C levels of the 2 groups were statistically analyzed,and the relationship between serum LDH and VEGF-C levels and clinicopathologic features of gastric cancer was analyzed,as well as univariate and multivariate prognostic factors affecting patients with gastric cancer.Results Serum LDH and VEGF-C levels were correlated with gastric cancer differentiation degree,TNM stage,lymph node metastasis and tumor diameter,but were not correlated with gender or age.Univariate analysis showed that the degree of tumor differentiation,TNM stage,lymph node metastasis,LDH and VEGF-C level were all factors influencing the poor prognosis of gastric cancer patients(P<0.05).Multivariate analysis showed that low differentiation,TNM stageⅲ-ⅳ,lymph node metastasis,LDH and VEGF-C levels were all factors influencing poor prognosis in gastric cancer patients(P<0.05).Serum LDH combined with VEGF-C has high diagnostic value for gastric cancer,with AUC of 0.877,95%CI of 0.783~0.925,sensitivity of 80.89%and specificity of 95.18%.Conclusion Serum LDH and VEGF-C levels in patients with gastric cancer are high,which are related to the differentiation degree of gastric cancer,TNM stage,lymph node metastasis and tumor diameter,and are independent risk factors affecting the prognosis of patients.The prognosis of patients can be predicted clinically by monitoring LDH and VEGF-C levels.