抗生素序贯疗法联合红外线治疗小儿急性肠系膜淋巴结炎的应用体会

Application of Sequential Antibiotic Therapy Combined with Infrared Ray in the Treatment of Acute Mesenteric Lymphadenitis in Children

目的:分析抗生素序贯疗法联合红外线治疗小儿急性肠系膜淋巴结炎的效果。方法:选取2022年6月—2023年6月遵义市第四人民医院收治的急性肠系膜淋巴结炎患儿68例作为研究对象,随机分为观察组和对照组,各34例。对照组采用抗生素序贯疗法,观察组在对照组基础上给予红外线照射治疗。比较两组临床指标、血常规指标、免疫功能指标及治疗效果。结果:治疗后3、7 d,两组淋巴结纵径、淋巴结横径小于治疗前,观察组小于对照组,差异有统计学意义(P<0.001);治疗后,两组降钙素原、白细胞计数、中性粒细胞百分比水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.001);治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于治疗前,观察组高于对照组,两组CD8^(+)水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.001);观察组治疗效果总有效率高于对照组,差异有统计学意义(P=0.018)。结论:在常规抗生素序贯疗法的基础上使用红外线照射治疗小儿急性肠系膜淋巴结炎的效果较好,可以减轻水肿,改善血常规和免疫指标。

Objective:To analyze the effect of sequential antibiotic therapy combined with infrared ray in the treatment of acute mesenteric lymphadenitis in children.Methods:Sixty-eight children with acute mesenteric lymphadenitis treated in Zunyi Fourth People's Hospital from June 2022 to June 2023 were selected as the study objects,and randomly divided into the observation group and the control group,with thirty-four cases in each group.The control group was treated with sequential antibiotic therapy,and the observation group was treated with infrared ray based on the control group.The clinical indexes,blood routine indexes,immune function indexes and therapeutic effects of the two groups were compared.Results:At 3 and 7 days after treatment,the longitudinal and transverse diameter of lymph nodes in the two groups were smaller than before treatment,and the observation group was smaller than the control group,the difference was statistically significant(P<0.001);after treatment,the levels of procalcitonin,white blood cell count and neutrophil percentage in the two groups were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.001);after treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than before treatment,the observation group was higher than control group,and the CD8^(+)level in two groups was lower than before treatment,the observation group was lower than control group,the difference was statistically significant(P<0.001);the total effective rate of treatment effect of the observation group was higher than that of the control group,the difference was statistically significant(P=0.018).Conclusion:On the basis of routine antibiotic sequential therapy,infrared ray is effective in the treatment of acute mesenteric lymphadytis in children,which can reduce edema and improve blood routine and immune indexes.