中西医结合治疗慢性阻塞性肺疾病合并呼吸衰竭的效果

Effect of Combined Chinese and Western Medicine in the Treatment of Chronic Obstructive Pulmonary Disease Combined with Respiratory Failure

目的:评估中西医结合疗法在慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者中的有效性。方法:选取2022年3月—2023年3月肇庆市广宁县中医院收治的COPD合并呼吸衰竭患者60例作为研究对象,根据随机数字表法分为对照组和观察组,各30例。对照组采用常规西医治疗方法,观察组采用中西医结合治疗方案。比较两组临床疗效、动脉血气指标、中医证候积分和血清炎性因子水平。结果:观察组临床疗效总有效率高于对照组,差异有统计学意义(P=0.023);治疗后,两组动脉血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))高于治疗前,动脉血二氧化碳分压(PaCO_(2))低于治疗前,观察组SaO_(2)、PaO_(2)高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05);治疗后,两组咳嗽、气短、喘息评分低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组C反应蛋白、白细胞介素-6、降钙素原水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。结论:相较于单纯西医治疗方法,中西医结合疗法治疗COPD合并呼吸衰竭患者效果更好,可改善患者临床症状、动脉血气及炎性因子水平。

Objective:To evaluate the effectiveness of combined Chinese and western medicine therapy in patients with chronic obstructive pulmonary disease(COPD)combined with respiratory failure.Methods:Sixty patients with COPD combined with respiratory failure admitted to Zhaoqing Guangning County Hospital of Traditional Chinese Medicine from March 2022 to March 2023 were selected as the study subjects,and were divided into a control group and an observation group of thirty cases each according to the method of randomized numerical table.The control group was treated with conventional western medicine,and the observation group was treated with a combination of Chinese and western medicine.The two groups were compared in terms of clinical efficacy,arterial blood gas indexes,Chinese medicine syndrome points and serum inflammatory factor levels.Results:The total effective rate of clinical efficacy of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.023);after treatment,the arterial blood oxygen saturation(SaO_(2))and arterial blood partial pressure of oxygen(PaO_(2))were higher than before treatment,and the arterial blood partial pressure of carbon dioxide(PaCO_(2))was lower than before treatment in the two groups,and SaO_(2) and PaO_(2) were higher in the observation group than the control group,and PaCO_(2) was lower than the control group,with a statistically significant difference(P<0.05);after treatment,the cough,shortness of breath and wheezing scores of the two groups were lower than before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05);after treatment,the levels of C-reactive protein,interleukin-6 and procalcitonin were lower than before treatment in both groups,and the observation group was lower than the control group,with statistically significant differences(P<0.05).Conclusion:Compared with the simple western medicine treatment method,the combined therapy of Chinese and western medicine is more effective in treating patients with COPD combined with respiratory failure,which can improve the clinical symptoms,arterial blood gases and inflammatory factor levels of the patients.