血清TG、Cys-C及GLUT5表达水平对IgA肾病患者发生高尿酸血症的预测价值

The predictive value of serum triacylglycerol,cystatin C and glucose transporter 5 levels for hyperuricemia in patients with IgA nephropathy

目的探讨血清三酰甘油(TG)、胱抑素C(Cys-C)及葡萄糖转运蛋白5(GLUT5)表达水平对原发性免疫球蛋白A(IgA)肾病患者发生高尿酸血症的预测价值。方法选取2021年1月-2022年12月本院IgA肾病患者120例,根据血尿酸(BUA)水平分为高尿酸血症组(n=57)和非高尿酸血症组(n=63)。比较2组一般资料、血清TG、Cys-C及GLUT5表达水平、CKD分期,分析BUA与血清TG、Cys-C及GLUT5相关性,以及各指标对IgA肾病患者发生高尿酸血症的预测价值。结果高尿酸血症组血清BUA、TG、Cys-C及GLUT5表达水平高于非高尿酸血症组(P<0.05);BUA与血清TG、Cys-C及GLUT5水平成正相关关系(P<0.05);2组CKD分期比较差异有统计学意义(P<0.05);血清TG、Cys-C及GLUT5联合预测高尿酸血症发生的AUC为0.893,敏感度为70.18%,特异度为95.24%,AUC及特异性优于各指标单独预测价值(P<0.05)。结论TG、Cys-C、GLUT5与IgA肾病伴高尿酸血症患者BUA水平具有一定相关性,三者联合检测对IgA肾病患者高尿酸血症发生具有良好预测价值,可为临床诊断及改善预后状况提供可靠理论依据。

Objective e This paper aims to explore the predictive value of serum triacylglycerol(TG),cystatin C(Cys-C)and glucose transporter 5(GLUT5)levels on hyperuricemia in patients with primary immunoglobulin A(IgA)nephropathy.Methods A total of 120 patients with IgA nephropathy in our hospital from January 2021 to December 2022 were divided into hyperuricemia group(n=57)and non-hyperuricemia group(n=63)according to the blood uric acid(BUA)level.General data,expression of serum TG,Cys-C and GLUT5,CKD staging of the two groups were compared,and the correlation between BUA and serum TG,Cys-C and GLUT5 was analyzed,as well as the predictive value of each index for hyperuricemia in IgA nephropathy patients.Results The levels of serum BUA,TG,Cys-C and GLUT5 in hyperuricemia group were higher than those in non-hyperuricemia group(P<0.05).BUA was positively correlated with serum TG,Cys-C and GLUT5 levels(P<0.05).There was statistical significance on the difference in CKD stages between the two groups(P<0.05).The AUC of serum TG,Cys-C and GLUT5 in predicting the occurrence of hyperuricemia was 0.893,the sensitivity was 70.18%,and the specificity was 95.24%,AUC and specificity were better than the individual predictive value of each index(P<0.05).Conclusion TG,Cys-C,CLUT5 have certain correlation with BUA level in patients with IgA nephropathy and hyperurice-mia.The combined detection of TG,Cys-C and GLUT5 has good predictive value for the occurrence of hyperuricemia in patients with IgA nephropathy,which can provide reliable theoretical basis for clinical diagnosis and improvement of prognosis.