亮菌口服溶液对肝癌术后患者免疫功能、肝功能及炎性因子的影响

Effects of Armillariella Oral Solution on Immune Function, Liver Function and Inflammatory Factors in Patients with Liver Cancer after Operation

目的 探讨亮菌口服溶液对肝癌术后患者免疫功能、肝功能及炎性因子的影响。方法 选取2019年2月—2020年3月收治的原发性肝癌94例,根据术后应用药物的不同均分为观察组和对照组。对照组在术后常规抗感染、护肝基础上加用恩替卡韦治疗,研究组在对照组基础上联合亮菌口服溶液治疗。比较2组临床疗效,治疗前后免疫功能指标、炎性因子、肝功能指标变化,治疗期间不良反应及无进展生存期(PFS)、总生存时间(OS)。结果 研究组治疗总有效率为95.74%(45/47)明显高于对照组的82.98%(39/47)(P<0.05)。治疗后2组CD3+、CD4+、CD8+、CD4+/CD8+及白蛋白水平均明显升高,且研究组较对照组明显升高(P<0.05,P<0.01)。治疗后2组C反应蛋白、白细胞介素-1、肿瘤坏死因子-α、白细胞介素-6及总胆红素、丙氨酸转氨酶、天冬氨酸转氨酶水平均降低,且研究组较对照组降低明显(P<0.05,P<0.01)。研究组不良反应总发生率明显低于对照组(P<0.05)。研究组PFS和OS均长于对照组(P<0.01)。结论 亮菌口服溶液可调节肝癌术后患者免疫功能,抗炎、抗肿瘤效果显著,并可有效促进患者肝功能恢复、延长患者生存期。

Objective To investigate the effects of Armillariella oral solution on immune function,liver function and inflammatory factors in patients with liver cancer after operation.Methods A total of 94 cases of primary liver cancer treated from February 2019 to March 2020 were selected and divided into research group and control group according to different postoperative drugs.The control group was treated with Entecavir on the basis of routine anti-infection and liver protection after operation,and the research group was treated with Armillariella oral solution on the basis of control group.The clinical efficacy,changes of immune function indexes,inflammatory factors,liver function indexes before and after treatment,adverse reactions,progression-free survival(PFS)and overall survival(OS)during treatment were compared between the two groups.Results The total effective rate of the research group was 95.74%(45/47),which was significantly higher than that of the control group[82.98%(39/47)](P<0.05).After treatment,the levels of CD3+,CD4+,CD8+,CD4+/CD8+and albumin in the two groups were significantly increased,which were significantly higher in the research group than in the control group(P<0.05,P<0.01).After treatment,the levels of C reactive protein,interleukin-1,tumor necrosis factor-α,interleukin-6,total bilirubin,alanine aminotransferase and aspartate aminotransferase in the two groups were decreased,and the levels in the research group were significantly lower than those in the control group(P<0.05,P<0.01).The total incidence of adverse reactions in the research group was significantly lower than that in control group(P<0.05).The PFS and OS of the research group were longer than those of the control group(P<0.01).Conclusion Armillariella oral solution can regulate the immune function of patients with liver cancer after operation,and has significant anti-inflammatory and anti-tumor effects,which can effectively promote the recovery of liver function and prolong the survival of patients.